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Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity

O'Brien, Mathew, Freeman, Kevin, Lum, Gary, Cheng, Allen C., Jacups, Susan P. and Currie, Bart J. (2004). Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity. Journal of Clinical Microbiology,42(5):2239-2240.

Document type: Journal Article
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Title Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity
Author O'Brien, Mathew
Freeman, Kevin
Lum, Gary
Cheng, Allen C.
Jacups, Susan P.
Currie, Bart J.
Journal Name Journal of Clinical Microbiology
Publication Date 2004
Volume Number 42
Issue Number 5
ISSN 0095-1137   (check CDU catalogue open catalogue search in new window)
Start Page 2239
End Page 2240
Total Pages 2
Place of Publication Washington, United States
Publisher American Society for Microbiology
Field of Research 1108 - Medical Microbiology
0605 - Microbiology
0707 - Veterinary Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract Immunochromatographic test (ICT) kits for the rapid detection of immunoglobulin G (IgG) and IgM antibodies to Burkholderia pseudomallei were compared to the indirect hemagglutination (IHA) assay. In 138 culture-confirmed melioidosis cases, sensitivities were 80, 77, and 88% for IHA, ICT IgG, and ICT IgM, respectively. In a prospective study of 160 consecutive sera samples sent for melioidosis serology, respective specificities were 91, 90, and 69, positive predictive values were 41, 32, and 18, and negative predictive values were 99, 98, and 100%. ICT IgM kits are unreliable for diagnosis of melioidosis, but ICT IgG kits may be useful for diagnosing travelers presenting with possible melioidosis who return from regions where melioidosis is endemic.
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Additional Notes Copyright by the American Society for Microbiology

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