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C-reactive protein in the diagnosis of melioidosis

Cheng, Allen C., OBrien, M., Jacups, S. P., Anstey, Nicholas M. and Currie, Bart J. (2004). C-reactive protein in the diagnosis of melioidosis. American Journal of Tropical Medicine and Hygiene,70(5):580-582.

Document type: Journal Article
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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ISI LOC 000221549700021
Title C-reactive protein in the diagnosis of melioidosis
Author Cheng, Allen C.
OBrien, M.
Jacups, S. P.
Anstey, Nicholas M.
Currie, Bart J.
Journal Name American Journal of Tropical Medicine and Hygiene
Publication Date 2004
Volume Number 70
Issue Number 5
ISSN 0002-9637   (check CDU catalogue open catalogue search in new window)
Start Page 580
End Page 582
Total Pages 3
Place of Publication US
Publisher American Society of Tropical Medicine and Hygiene
Field of Research 1117 - Public Health and Health Services
HERDC Category C1 - Journal Article (DEST)
Abstract Previous work suggested that C-reactive protein (CRP) may be a useful test in the diagnosis of melioidosis, the infection caused by Burkholderia pseudomallei. We reviewed patients with culture-confirmed melioidosis to define the role of this inflammatory marker in the diagnosis of melioidosis. In 175 patients, we found that the admission CRP level may be normal or only mildly elevated, including patients with severe sepsis, fatal cases, and in relapsed melioidosis. In a multivariate analysis, sepsis and bacteremia were more strongly associated with mortality than CRP. Admission levels of CRP are not a sensitive marker for the presence of melioidosis and a normal level cannot be used to exclude acute, chronic, or relapsed melioidosis in febrile patients in or from endemic regions.
Keywords respiratory-tract infection
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