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First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei

Currie, Bart J., Harumal, Pearly, McKinnon, Melita and Walton, Shelley F. (2004). First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei. Clinical Infectious Diseases,39(1):e8-e12.

Document type: Journal Article
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Title First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei
Author Currie, Bart J.
Harumal, Pearly
McKinnon, Melita
Walton, Shelley F.
Journal Name Clinical Infectious Diseases
Publication Date 2004
Volume Number 39
Issue Number 1
ISSN 1058-4838   (check CDU catalogue open catalogue search in new window)
Start Page e8
End Page e12
Total Pages 5
Place of Publication US
Publisher University of Chicago Press
Field of Research 1103 - Clinical Sciences
1108 - Medical Microbiology
0605 - Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Ivermectin is increasingly being used to treat scabies, especially crusted (Norwegian) scabies. However, treatment failures, recrudescence, and reinfection can occur, even after multiple doses. Ivermectin resistance has been documented for some intestinal helminths in animals with intensive ivermectin exposure. Ivermectin resistance has also been induced in arthropods in laboratory experiments but, to date, has not been documented among arthropods in nature. We report clinical and in vitro evidence of ivermectin resistance in 2 patients with multiple recurrences of crusted scabies who had previously received 30 and 58 doses of ivermectin over 4 and 4.5 years, respectively. As predicted, ivermectin resistance in scabies mites can develop after intensive ivermectin use
DOI http://dx.doi.org/10.1086/421776   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes 2639 (Journal)
 
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