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Acaricidal Activity of Melaleuca alternifolia (Tea Tree) Oil: In Vitro Sensitivity of Sarcoptes scabiei var hominis to Terpinen-4-ol

Walton, Shelley F., McKinnon, Melita, Pizzutto, Susan J., Dougall, Annette, Williams, Edwina and Currie, Bart J. (2004). Acaricidal Activity of Melaleuca alternifolia (Tea Tree) Oil: In Vitro Sensitivity of Sarcoptes scabiei var hominis to Terpinen-4-ol. Archives of Dermatology,140(5):563-566.

Document type: Journal Article
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Title Acaricidal Activity of Melaleuca alternifolia (Tea Tree) Oil: In Vitro Sensitivity of Sarcoptes scabiei var hominis to Terpinen-4-ol
Author Walton, Shelley F.
McKinnon, Melita
Pizzutto, Susan J.
Dougall, Annette
Williams, Edwina
Currie, Bart J.
Journal Name Archives of Dermatology
Publication Date 2004
Volume Number 140
Issue Number 5
ISSN 0003-987X   (check CDU catalogue  open catalogue search in new window)
Start Page 563
End Page 566
Total Pages 4
Place of Publication US
Publisher American Medical Association
Field of Research 1103 - Clinical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract Objective: To compare the acaricidal activity of Melaleuca alternifolia (tea tree) oil (TTO) and some of its individual active components on the itch mite Sarcoptes scabiei var hominis.

Design: In vitro acaricide sensitivity assessment.

Setting:
The Menzies School of Health Research laboratory, located near the Infectious Diseases Ward of the Royal Darwin Hospital, Australia, where patients are admitted and treated for crusted scabies.

Participants:
Scabies mites (S scabiei var hominis) were collected from a 20-year-old Aboriginal woman admitted to the Royal Darwin Hospital with crusted scabies.

Interventions: Within 3 hours of collection, scabies mites were placed in continuous direct contact with the TTO products and control acaricides and were observed at regular intervals.

Main Outcome Measures: Percentage of mites dead at regular observation intervals between 5 minutes and 24 hours during continuous exposure to the TTO products and acaricides.

Results:
The 5% TTO and active component terpinen-4-ol were highly effective in reducing mite survival times. Statistically significant differences in mite survival curves were observed for 5% TTO, 2.1% terpinen-4-ol, 5% permethrin, and ivermectin (100 μg/g of Emulsifying Ointment British Pharmacopoeia 88). In vivo effectiveness was also observed.

Conclusions: Documentation of resistance against antiectoparasitic
compounds is increasing. Reported S scabiei treatment failures with lindane, crotamiton, and benzyl benzoate, as well as likely emerging resistance to 5% permethrin and oral ivermectin, are of concern and advocate for the identification and development of novel acaricidal drugs. Tea tree oil is a membrane-active biocide extracted from the tree M alternifolia. It is a principal antimicrobial in a wide range of pharmaceuticals sold in Australia, with themain active component being oxygenated terpenoids. The results suggest that TTO has a potential role as a new topical acaricide and confirm terpinen-4-ol as the primary active component.
DOI http://dx.doi.org/10.1001/archderm.140.5.563   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
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URL http://archderm.ama-assn.org/cgi/reprint/140/5/563?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=Acaricidal+Activity+of+Melaleuca+alternifolia+%28Tea+Tree%29+Oil%3A+In+Vitro+Sensitivity+of+Sarcoptes+scabiei+var+hominis+to+Terpinen-4-ol&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
 
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