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The fibronectin-binding capacity and host cell adherence of Streptococcus pyogenes strains are discordant with each other

Edwards, Mandy, Fagan, Peter K., Currie, Bart J. and Sriprakash, Kadaba S. (2004). The fibronectin-binding capacity and host cell adherence of Streptococcus pyogenes strains are discordant with each other. Microbes and Infection,6(13):1156-1162.

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Title The fibronectin-binding capacity and host cell adherence of Streptococcus pyogenes strains are discordant with each other
Author Edwards, Mandy
Fagan, Peter K.
Currie, Bart J.
Sriprakash, Kadaba S.
Journal Name Microbes and Infection
Publication Date 2004
Volume Number 6
Issue Number 13
ISSN 1286-4579   (check CDU catalogue open catalogue search in new window)
Start Page 1156
End Page 1162
Total Pages 7
Place of Publication France
Publisher Elsevier Masson
Field of Research 1107 - Immunology
1108 - Medical Microbiology
0605 - Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Surface exposed fibronectin-binding proteins (FBPs) play an important role in the adherence of Streptococcus pyogenes (group A streptococcus, GAS) to host cells. This pathogen expresses numerous FBPs, of which SfbI, SfbII and PrtF2 are major surface exposed FBPs. However, GAS strains differ in the genetic potential to express these proteins. To test whether this difference reflects in differences in fibronectin (Fn) binding, a set of circulating strains previously examined for adherence to host cells was used. The 68 distinct strains were isolated from throat, skin and blood. They were analyzed for (a) the presence of genes for SfbI, SfbII and PrtF2 and (b) the extent of Fn binding. The results suggest that strains possessing two or more of the genes for these FBPs bound Fn significantly more than strains possessing none or one of the genes. No correlation between the extent of Fn binding and the tissue site of isolation was found. Furthermore, together with our previous studies on adherence capacity of these GAS strains, we found no correlation between Fn binding ability and the avidity of the strains to adhere to epithelial cells. We suggest that while Fn binding is important for adhesion, for many GAS strains the extent of Fn binding is not the critical determinant of adherence.
Keywords streptococcus pyogenes
fibronectin-binding proteins
host cell adhesion
inhibition of adhesion
DOI http://dx.doi.org/10.1016/j.micinf.2004.06.007   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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