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Genetic epidemiology of Sarcoptes scabiei (Acari: Sarcoptidae) in northern Australia

Walton, Shelley F., Dougall, Annette, Pizzutto, Susan J., Holt, Deborah C., Taplin, D., Arlian, L. G., Morgan, M., Currie, Bart J. and Kemp, David J. (2004). Genetic epidemiology of Sarcoptes scabiei (Acari: Sarcoptidae) in northern Australia. International Journal for Parasitology,34(7):839-849.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 49 times in Scopus Article | Citations

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Title Genetic epidemiology of Sarcoptes scabiei (Acari: Sarcoptidae) in northern Australia
Author Walton, Shelley F.
Dougall, Annette
Pizzutto, Susan J.
Holt, Deborah C.
Taplin, D.
Arlian, L. G.
Morgan, M.
Currie, Bart J.
Kemp, David J.
Journal Name International Journal for Parasitology
Publication Date 2004
Volume Number 34
Issue Number 7
ISSN 0020-7519   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-2442608389
Start Page 839
End Page 849
Total Pages 11
Place of Publication Oxford, UK
Publisher Elsevier Science
Field of Research 0707 - Veterinary Sciences
0605 - Microbiology
0608 - Zoology
HERDC Category C1 - Journal Article (DEST)
Abstract Utilising three hypervariable microsatellite markers we have previously shown that scabies mites on people are genetically distinct from those on dogs in sympatric populations in northern Australia. This had important ramifications on the formulation of public health control policies. In contrast phylogenetic analyses using mitochondrial markers on scabies mites infecting multiple animal hosts elsewhere in the world could not differentiate any genetic variation between mite haplotype and host species. Here we further analyse the intra-specific relationship of Sarcoptes scabiei var. hominis with S. scabiei var. canis by using both mitochondrial DNA and an expanded nuclear microsatellite marker system. Phylogenetic studies using sequences from the mitochondrial genes coding for 16S rRNA and Cytochrome Oxidase subunit I demonstrated significant relationships between S. scabiei MtDNA haplotypes, host species and geographical location. Multi-locus genotyping using 15 microsatellite markers substantiated previous data that gene flow between scabies mite populations on human and dog hosts is extremely rare in northern Australia. These data clearly support our previous contention that control programs for human scabies in endemic areas with sympatric S. scabiei var. hominis and var. canis populations must focus on human-to-human transmission. The genetic division of dog and human derived scabies mites also has important implications in vaccine and diagnostic test development as well as the emergence and monitoring of drug resistance in S. scabiei in northern Australia.
Keywords Sarcoptes scabiei
Scabies
16S rRNA
Cytochrome oxidase
Microsatellite
Phylogeny
DOI http://dx.doi.org/10.1016/j.ijpara.2004.04.002   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes 2669 (Journal)
 
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