Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis

Cheng, Allen C., Stephens, D. P., Anstey, Nicholas M. and Currie, Bart J. (2004). Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis. Clinical Infectious Diseases,38(1):32-37.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 1
Google Scholar Search Google Scholar

Title Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis
Author Cheng, Allen C.
Stephens, D. P.
Anstey, Nicholas M.
Currie, Bart J.
Journal Name Clinical Infectious Diseases
Publication Date 2004
Volume Number 38
Issue Number 1
ISSN 1058-4838   (check CDU catalogue  open catalogue search in new window)
Start Page 32
End Page 37
Total Pages 6
Place of Publication US
Publisher University of Chicago Press
Field of Research 1103 - Clinical Sciences
1108 - Medical Microbiology
0605 - Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Melioidosis, caused by the intracellular pathogen Burkholderia pseudomallei, is endemic in northern Australia and Southeast Asia. Risk factors for this infection have also been associated with functional neutrophil defects. Because of this, granulocyte colony-stimulating factor (G-CSF) was adopted for use in patients with septic shock due to melioidosis in December 1998. We compared the mortality rates from before and after the introduction of G-CSF therapy at the Royal Darwin Hospital (Darwin, Australia) during the period of 1989-2002. The mortality rate decreased from 95% to 10% after the introduction of G-CSF. Risk factors, the duration of illness before presentation, and the severity of illness were similar in both groups. A smaller decrease in mortality among patients in the intensive care unit who did not have melioidosis was observed, suggesting that other changes in management did not account for the magnitude of the benefit seen. We conclude that G-CSF may have contributed to the reduction in the mortality rate among patients with septic shock due to melioidosis.
DOI http://dx.doi.org/10.1086/380456   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
Versions
Version Filter Type
Access Statistics: 72 Abstract Views  -  Detailed Statistics
Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator