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Intranasal vaccination with Streptococcal fibronectin binding protein Sfb1 fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model

McArthur, J., Medina, E., Mueller, A., Chin, J., Currie, Bart J., Sriprakash, Kadaba S., Talay, S. R., Chhatwal, G. S. and Walker, M. J. (2004). Intranasal vaccination with Streptococcal fibronectin binding protein Sfb1 fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model. Infection and Immunity,72(12):7342-7345.

Document type: Journal Article
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Title Intranasal vaccination with Streptococcal fibronectin binding protein Sfb1 fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model
Author McArthur, J.
Medina, E.
Mueller, A.
Chin, J.
Currie, Bart J.
Sriprakash, Kadaba S.
Talay, S. R.
Chhatwal, G. S.
Walker, M. J.
Journal Name Infection and Immunity
Publication Date 2004
Volume Number 72
Issue Number 12
ISSN 0019-9567   (check CDU catalogue open catalogue search in new window)
Start Page 7342
End Page 7345
Total Pages 4
Place of Publication Washington, United States
Publisher American Society of Microbiology
Field of Research 1103 - Clinical Sciences
0605 - Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Fibronectin binding protein F1 (Sfb1) of Streptococcus pyogenes (group A streptococcus [GAS]) is a well-characterized adhesin that has been shown to induce protection in mice against a lethal intranasal GAS challenge after intranasal immunization with cholera toxin B subunit (CTB) as adjuvant. With a murine skin infection model, we have shown that Sfb1/CTB vaccination neither elicits opsonizing antibodies nor prevents systemic bacterial growth and dissemination to internal organs after a subcutaneous GAS challenge. These results indicate that an Sfb1-based vaccine should be complemented with additional protective antigens in order to be used in areas such as the tropical north of Australia, where the skin is the primary route of entry for invasive streptococcal diseases.
DOI http://dx.doi.org/10.1128/IAI.72.12.7342-7345.2004   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes Copyright by the American Society of Microbiology


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