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Nitric oxide production and nitric oxide synthase activity in malaria-exposed Papua New Guinean children and adults show longitudinal stability and no association with parasitemia

Boutlis, Craig S., Weinberg, J. Brice, Baker, Joanne, Bockarie, Moses J., Mgone, Charles S., Cheng, Qin and Anstey, Nicholas M. (2004). Nitric oxide production and nitric oxide synthase activity in malaria-exposed Papua New Guinean children and adults show longitudinal stability and no association with parasitemia. Infection and Immunity,72(12):6932-6938.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 15 times in Scopus Article | Citations

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Title Nitric oxide production and nitric oxide synthase activity in malaria-exposed Papua New Guinean children and adults show longitudinal stability and no association with parasitemia
Author Boutlis, Craig S.
Weinberg, J. Brice
Baker, Joanne
Bockarie, Moses J.
Mgone, Charles S.
Cheng, Qin
Anstey, Nicholas M.
Journal Name Infection and Immunity
Publication Date 2004
Volume Number 72
Issue Number 12
ISSN 0019-9567   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-9244252536
Start Page 6932
End Page 6938
Total Pages 7
Place of Publication Washington, United States
Publisher American Society for Microbiology
Field of Research 0605 - Microbiology
1103 - Clinical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract Individuals in areas of intense malaria transmission exhibit resistance (or tolerance) to levels of parasitemia in their blood that would normally be associated with febrile illness in malaria-naive subjects. The resulting level of parasitemia associated with illness (the pyrogenic threshold) is highest in childhood and lowest in adulthood. Clinical parallels between malarial and bacterial endotoxin tolerance have led to the supposition that both share common physiological processes, with nitric oxide (NO) proposed as a candidate mediator. The hypotheses that NO mediates tolerance and blood stage parasite killing in vivo were tested by determining its relationship to age and parasitemia cross-sectionally and longitudinally in a population of 195 children and adults from Papua New Guinea encountering intense malaria exposure. Despite pharmacological clearance of asymptomatic parasitemia, NO production and mononuclear cell NO synthase (NOS) activity were remarkably stable within individuals over time, were not influenced by parasitemia, and varied little with age. These results contrast with previous smaller cross-sectional studies. Baseline NO production and NOS activity did not protect against recurrent parasitemia, consistent with previous data suggesting that NO does not have antiparasitic effects against blood stage infection in vivo. The NO indices studied were markedly higher in specimens from study subjects than in samples from Australian controls, and NOS activity was significantly associated with plasma immunoglobulin E levels, consistent with induction of NO by chronic exposure to other infections and/or host genetic factors. These results suggest that NO is unlikely to mediate killing of blood stage parasites in this setting and is unlikely to be the primary mediator in the acquisition or maintenance of malarial tolerance.
DOI http://dx.doi.org/10.1128/IAI.72.12.6932-6938.2004   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes Copyright by the American Society for Microbiology


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