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Plasminogen binding by goup A Streptococcal isolates from a region of hyperendemicity for Streptococcal skin infection and a high incidence of invasive infection

McKay, Fiona C., McArthur, Jason D., Sanderson-Smith, Martina L., Gardam, Sandra, Currie, Bart J., Sriprakash, Kadaba S., Fagan, Peter K., Towers, Rebecca J., Batzloff, Michael R., Chhatwal, Gursharan S., Ranson, Marie and Walker, Mark J. (2004). Plasminogen binding by goup A Streptococcal isolates from a region of hyperendemicity for Streptococcal skin infection and a high incidence of invasive infection. Infection and Immunity,72(1):364-370.

Document type: Journal Article
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Title Plasminogen binding by goup A Streptococcal isolates from a region of hyperendemicity for Streptococcal skin infection and a high incidence of invasive infection
Author McKay, Fiona C.
McArthur, Jason D.
Sanderson-Smith, Martina L.
Gardam, Sandra
Currie, Bart J.
Sriprakash, Kadaba S.
Fagan, Peter K.
Towers, Rebecca J.
Batzloff, Michael R.
Chhatwal, Gursharan S.
Ranson, Marie
Walker, Mark J.
Journal Name Infection and Immunity
Publication Date 2004
Volume Number 72
Issue Number 1
ISSN 0019-9567   (check CDU catalogue open catalogue search in new window)
Start Page 364
End Page 370
Total Pages 7
Place of Publication Washington, United States
Publisher American Society for Microbiology
Field of Research 1103 - Clinical Sciences
0605 - Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Reports of resurgence in invasive group A streptococcal (GAS) infections come mainly from affluent populations with infrequent exposure to GAS. In the Northern Territory (NT) of Australia, high incidence of invasive GAS disease is secondary to endemic skin infection, serotype M1 clones are rare in invasive infection, the diversity and level of exposure to GAS strains are high, and no particular strains dominate. Expression of a plasminogen-binding GAS M-like protein (PAM) has been associated with skin infection in isolates elsewhere (D. Bessen, C. M. Sotir, T. M. Readdy, and S. K. Hollingshead, J. Infect. Dis. 173:896-900, 1996), and subversion of the host plasminogen system by GAS is thought to contribute to invasion in animal models. Here, we describe the relationship between plasminogen-binding capacity of GAS isolates, PAM genotype, and invasive capacity in 29 GAS isolates belonging to 25 distinct strains from the NT. In the presence of fibrinogen and streptokinase, invasive isolates bound more plasminogen than isolates from uncomplicated infections (P 0.004). Only PAM-positive isolates bound substantial levels of plasminogen by a fibrinogen-streptokinase-independent pathway (direct binding). Despite considerable amino acid sequence variation within the A1 repeat region of PAM where the plasminogen-binding domain maps, the critical lysine residue was conserved.
DOI http://dx.doi.org/10.1128/IAI.72.1.364-370.2004   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes Copyright by the American Society for Microbiology


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