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Inhibition of Streptococcus pyogenes adherence to HaCaT cells by a peptide corresponding to the streptococcal fibronectin-binding protein, SfbI, is strain dependent

Edwards, M. L., Fagan, Peter K., Towers, Rebecca J., Currie, Bart J. and Sriprakash, Kadaba S. (2004). Inhibition of Streptococcus pyogenes adherence to HaCaT cells by a peptide corresponding to the streptococcal fibronectin-binding protein, SfbI, is strain dependent. Microbes and Infection,6(10):926-928.

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Title Inhibition of Streptococcus pyogenes adherence to HaCaT cells by a peptide corresponding to the streptococcal fibronectin-binding protein, SfbI, is strain dependent
Author Edwards, M. L.
Fagan, Peter K.
Towers, Rebecca J.
Currie, Bart J.
Sriprakash, Kadaba S.
Journal Name Microbes and Infection
Publication Date 2004
Volume Number 6
Issue Number 10
ISSN 1286-4579   (check CDU catalogue  open catalogue search in new window)
Start Page 926
End Page 928
Place of Publication Paris, France
Publisher Elsevier
HERDC Category C2 - Journal Article - Other contributions to refereed journal (internal)
Abstract Streptococcus pyogenes (group A streptococcus, GAS) is a human-specific pathogen, which employs a large number of adhesins for colonization. Fibronectin-binding proteins (FBPs) play a major role in GAS adhesion to host cells. SfbI, a major streptococcal FBP, has been well studied. A peptide (peptide-MSG) based on this adhesin inhibits fibronectin (Fn)-binding by the pathogen. To test whether this peptide also inhibits adherence of GAS to host cells, adhesion assays were performed with strains possessing different combinations of genes for three distinct FBPs. Peptide-MSG inhibited GAS adherence to human keratinocytes (HaCaT) in a strain dependent manner. There is no consistent pattern between the effect and the ability to express one or more of the FBPs. A single peptide may be insufficient to prevent GAS adherence to host cells.
Keywords streptococcus pyogenes
fibronectin-binding proteins
adherence
group-a streptococci
serum opacity factor
synthetic peptide
adhesin
australia
domains
DOI http://dx.doi.org/10.1016/j,micinf.2004.05.006   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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