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Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea

Trenholme, K., Boutlis, Craig S., Kuns, R., Lagog, M., Bockarie, M., Gatton, M., Kemp, D., Good, M., Anstey, Nicholas M. and Gardiner, D. (2005). Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea. American Journal of Tropical Medicine and Hygiene,72(6):708-713.

Document type: Journal Article
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IRMA ID 10002xPUB42
Title Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea
Author Trenholme, K.
Boutlis, Craig S.
Kuns, R.
Lagog, M.
Bockarie, M.
Gatton, M.
Kemp, D.
Good, M.
Anstey, Nicholas M.
Gardiner, D.
Journal Name American Journal of Tropical Medicine and Hygiene
Publication Date 2005
Volume Number 72
Issue Number 6
ISSN 0002-9637   (check CDU catalogue open catalogue search in new window)
Start Page 708
End Page 713
Total Pages 6
Place of Publication US
Publisher American Society of Tropical Medicine and Hygiene
Field of Research 1117 - Public Health and Health Services
HERDC Category C1 - Journal Article (DEST)
Abstract The cytoadherence-linked asexual gene 9 (clag 9) of Plasmodium falciparum has been implicated in the cytoadherence of infected erythrocytes. To determine the immunogenicity of the clag 9 gene product (CLAG 9 protein) in humans, we measured antibody responses to 11 synthetic CLAG 9 peptides in a group of 177 asymptomatic children and adults subject to intense malaria exposure in Madang, Papua New Guinea. The CLAG 9 peptides were immunogenic in adults and children. Antibody responses to peptides 4 and 10 were high across all age groups and detectable in a majority of children less than five years of age. While CLAG 9 peptides are immunogenic in humans, longitudinal studies will be required to determine the longevity of antibody responses to CLAG 9 and their role in protection from disease.
Additional Notes 2920 (Journal)
Description for Link Link to published version
URL http://www.ajtmh.org/cgi/reprint/72/6/708
 
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