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Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei

Wuthiekanun, V., Cheng, Allen C., Chierakul, W., Amornchai, Premjit, Limmathurotsakul, D., Chaowagul, W., Simpson, A. J. H., Short, J. M., Wongsuvan, G., Maharjan, B., White, Nicholas J. and Peacock, S. J. (2005). Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei. Journal of Antimicrobial Chemotherapy,55:1029-1031.

Document type: Journal Article
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Title Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei
Author Wuthiekanun, V.
Cheng, Allen C.
Chierakul, W.
Amornchai, Premjit
Limmathurotsakul, D.
Chaowagul, W.
Simpson, A. J. H.
Short, J. M.
Wongsuvan, G.
Maharjan, B.
White, Nicholas J.
Peacock, S. J.
Journal Name Journal of Antimicrobial Chemotherapy
Publication Date 2005
Volume Number 55
ISSN 0305-7453   (check CDU catalogue open catalogue search in new window)
Start Page 1029
End Page 1031
Place of Publication United Kingdom
Publisher Oxford University Press
HERDC Category C1 - Journal Article (DEST)
Abstract Objectives: Trimethoprim/sulfamethoxazole is commonly used to treat melioidosis. Antimicrobial susceptibility testing using the disc diffusion method is commonly used in melloidosis-endemic areas, but may overestimate resistance to trimethoprim/sulfamethoxazole. Patients and methods: We performed disc diffusion and Etest on isolates from the first positive culture for all patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani, Thailand, with cultureconfirmed melioldosis between 1992 and 2003. Results: The estimated resistance rate for 1976 clinical Burkholderia pseudomallei isolates was 13% by Etest and 71% by disc diffusion. All isolates classed as either susceptible (n = 358) or as having intermediate resistance (n = 218) on disc diffusion were susceptible by Etest. Only 258 of the 1400 (18%) isolates classed as resistant on disc diffusion were resistant by Etest. Conclusions: Disc diffusion testing of B. pseudomallei may be useful as a limited screening tool in resource poor settings. Isolates assigned as 'susceptible' or 'intermediate' by disc diffusion may be viewed as 'susceptible'; those assigned as 'resistant' require further evaluation by MIC methodology.
Keywords burkholderia pseudomallei
antibiotic susceptibility
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