Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Lung injury in uncomplicated and severe falciparum malaria: A longitudinal study in Papua, Indonesia

Maguire, Graeme P., Handojo, Tjandra, Pain, Michael C. F., Kenangalem, Enny, Price, Ric N., Tjitra, Emiliana and Anstey, Nicholas M. (2005). Lung injury in uncomplicated and severe falciparum malaria: A longitudinal study in Papua, Indonesia. Journal of Infectious Diseases,192(11):1966-1974.

Document type: Journal Article
Citation counts:
Google Scholar Search Google Scholar

IRMA ID 10202xPUB34
Title Lung injury in uncomplicated and severe falciparum malaria: A longitudinal study in Papua, Indonesia
Author Maguire, Graeme P.
Handojo, Tjandra
Pain, Michael C. F.
Kenangalem, Enny
Price, Ric N.
Tjitra, Emiliana
Anstey, Nicholas M.
Journal Name Journal of Infectious Diseases
Publication Date 2005
Volume Number 192
Issue Number 11
ISSN 0022-1899   (check CDU catalogue  open catalogue search in new window)
Start Page 1966
End Page 1974
Total Pages 9
Place of Publication US
Publisher University of Chicago Press
Field of Research 1103 - Clinical Sciences
1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Background: In patients with severe malaria, acute respiratory distress syndrome usually develops after the start of drug treatment and is a major cause of death. Its pathogenesis is not well understood.

Methods: Respiratory symptom, spirometry, and gas transfer analyses were performed longitudinally in adults in Papua, Indonesia, with uncomplicated ( ) and severe ( ) falciparum malaria; normal values were derived from 109 control subjects. Gas transfer was partitioned into its alveolar‐capillary membrane (DM) and pulmonary vascular (Vc) components, to characterize the site of impaired gas transfer.

Results: Cough was frequent in both patients with uncomplicated malaria (50%) and those with severe malaria (30%) and resolved by day 14. Reduced midexpiratory flow indicated obstruction of the small airways. Gas transfer was significantly impaired in patients with severe malaria. DM was reduced in patients with severe malaria but not in those with uncomplicated malaria and only returned to normal levels after 2 weeks. In patients with uncomplicated malaria, Vc was reduced at presentation but improved thereafter. In patients with severe malaria, Vc decreased with treatment and was lowest at day 7.

Conclusions: Our results suggest that pulmonary vascular occlusion occurs in both patients with uncomplicated malaria and those with severe malaria, likely from sequestration of both red blood cells (RBCs) and white blood cells. There was also impaired alveolar‐capillary membrane function in patients with severe malaria but not in those with uncomplicated malaria. Persistent impairment long after clearance of parasitized RBCs suggests prolonged posttreatment inflammatory alveolar‐capillary injury.
Keywords blood-cell deformability
diffusing-capacity
pulmonary-edema
pathophysiology
pneumonia
membrane
DOI http://dx.doi.org/10.1086/497697   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
Versions
Version Filter Type
Access Statistics: 38 Abstract Views  -  Detailed Statistics
Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator