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Central obesity is associated with reduced peripheral wave reflection in Indigenous Australians irrespective of diabetes status

Maple-Brown, Louise, Piers, Leonard, O'Rourke, Michael, Celermajer, David and O'Dea, Kerin (2005). Central obesity is associated with reduced peripheral wave reflection in Indigenous Australians irrespective of diabetes status. Journal of Hypertension,23(7):1403-1407.

Document type: Journal Article
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IRMA ID 10426xPUB11
Title Central obesity is associated with reduced peripheral wave reflection in Indigenous Australians irrespective of diabetes status
Author Maple-Brown, Louise
Piers, Leonard
O'Rourke, Michael
Celermajer, David
O'Dea, Kerin
Journal Name Journal of Hypertension
Publication Date 2005
Volume Number 23
Issue Number 7
ISSN 0263-6352   (check CDU catalogue  open catalogue search in new window)
Start Page 1403
End Page 1407
Total Pages 5
Place of Publication UK
Publisher Lippincott Williams & Wilkins
HERDC Category C1 - Journal Article (DEST)
Abstract Objective: To determine the influence of central obesity and type 2 diabetes on peripheral wave reflection in Indigenous Australians.

Design and methods: A cross-sectional study of remote Indigenous Australians with (n = 43) and without (n = 54) type 2 diabetes of similar age (47 years) and sex; using anthropometric and bioelectrical impedance measures of obesity and applanation tonometry to determine the aortic augmentation index (AI) as an index of peripheral wave relfection.

Results: Indices of obesity were significantly higher in the diabetic than non-diabetic participants [body mass index (BMI): 27.3 versus 24.6 kg/m2, P = 0.018; waist circumference: women 101 versus 94 cm, P = 0.008, men 102 versus 91 cm, P = 0.039]. AI was negatively related to obesity: BMI (r = -0.35, P = 0.0003), weight (r = -0.44, P < 0.0005), waist circumference (r = -0.34, P = 0.0003) and fat mass (r = -0.35, P < 0.0005). There was no significant difference in AI between the groups with and without diabetes. On multiple regression analysis, 66% of the variance in AI was explained with the following significant predictors: age, heart rate, male gender, fat mass and mean arterial pressure. Similar results were obtained when weight, waist circumference or BMI were substituted for fat mass.

Conclusion: When compared with Indigenous Australians without diabetes, those with type 2 diabetes do not have greater aortic pressure augmentation from peripheral wave reflection. However, obesity, irrespective of the index used, was related to lower peripheral wave reflection in both those with and without type 2 diabetes.
Keywords aboriginal
arterial stiffness
augmentation index
central obesity
type 2 diabetes
large artery stiffness
central systolic pressure
insulin-induced decreases
body-mass index
augmentation index
fat distribution
aortic pressure
renal-failure
women
resistance
DOI http://dx.doi.org/10.1097/01.hjh.0000173524.80802.5a   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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