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Impaired systemic production of Prostoglandin E2 in children with cerebral malaria

Perkins, DJ, Hittner, JB, Mwaikambo,, ED, Granger, DL, Weinberg, JB and Anstey, Nicholas M. (2005). Impaired systemic production of Prostoglandin E2 in children with cerebral malaria. Journal of Infectious Diseases,191(9):1548-1556.

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Title Impaired systemic production of Prostoglandin E2 in children with cerebral malaria
Author Perkins, DJ
Hittner, JB
Mwaikambo,, ED
Granger, DL
Weinberg, JB
Anstey, Nicholas M.
Journal Name Journal of Infectious Diseases
Publication Date 2005
Volume Number 191
Issue Number 9
ISSN 0022-1899   (check CDU catalogue open catalogue search in new window)
Start Page 1548
End Page 1556
Place of Publication United States
Publisher The University of Chicago Press
HERDC Category C1 - Journal Article (DEST)
Abstract Prostaglandins (PGs) are important mediators of macrophage activity, vascular permeability, fever, erythropoiesis, and proinflammatory responses to infection. Our recent studies have shown that plasma levels of bicyclo-PGE2 (a stable end product of PGE2 metabolism) and leukocyte cyclooxygenase (COX)-2 gene expression are suppressed in children with malarial anemia. Since the role of PGs as immunomodulators of human cerebral malaria (CM) has not been examined, we investigated urinary levels of bicyclo-PGE2/creatinine in children with varying clinical outcomes of CM. Among parasitemic children, those with asymptomatic parasitemia had the highest levels of bicyclo-PGE2/creatinine, whereas those with CM had significantly lower levels of bicyclo-PGE2. Systemic levels of bicyclo-PGE2/creatinine were not significantly associated with parasitemia, hemoglobin levels, or levels of the PG-regulatory cytokine tumor necrosis factor- alpha but were positively correlated with levels of interleukin-10. The results presented here show that impaired systemic production of PGE2 is associated with adverse outcomes of CM, whereas elevated levels of PGE2 in asymptomatic parasitemia suggest a potential role for PGs in protective immunity.
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Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator