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Current issues regarding the use of pneumococcal conjugate and polysaccharide vaccines in Australian children

Mackenzie, Grant, Carapetis, Jonathan R., Morris, Peter S. and Leach, Amanda J. (2005). Current issues regarding the use of pneumococcal conjugate and polysaccharide vaccines in Australian children. Journal of Paediatrics and Child Health,41(4):201-208.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 8 times in Scopus Article | Citations

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IRMA ID 10414xPUB48
Title Current issues regarding the use of pneumococcal conjugate and polysaccharide vaccines in Australian children
Author Mackenzie, Grant
Carapetis, Jonathan R.
Morris, Peter S.
Leach, Amanda J.
Journal Name Journal of Paediatrics and Child Health
Publication Date 2005
Volume Number 41
Issue Number 4
ISSN 1034-4810   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-18444400232
Start Page 201
End Page 208
Total Pages 8
Place of Publication UK
Publisher Wiley-Blackwell Publishing
Field of Research 1114 - Paediatrics and Reproductive Medicine
HERDC Category C1 - Journal Article (DEST)
Abstract Objective:  To present the results of child pneumococcal vaccination studies in the setting of current Australian disease epidemiology and immunization policy, and issues that clinicians should consider in discussions with families.

Methods:  This paper includes a narrative review of randomized, controlled, double blind studies and systematic reviews which evaluated the efficacy of child pneumococcal vaccination.

Results:  7PCV is expected to prevent >80% of childhood invasive pneumococcal disease (IPD, includes meningitis, septicaemia/bacteraemia) and the associated mortality. 7PCV may prevent 6% of all pneumonia, 18% of radiographically-defined pneumonia, 6% of all otitis media (OM) and 20%–40% of tympanostomy tube procedures. It may also reduce IPD due to antibiotic-resistant pneumococci, and prevent IPD in unvaccinated individuals. The impact of replacement disease caused by non-vaccine serotypes is not yet known. Pneumococcal polysaccharide vaccines given to 2-year-old children may prevent approximately 19% of all and 26% of recurrent OM.

Conclusion:  The Australian Standard Vaccination Schedule recommends universal infant immunization with seven-valent pneumococcal conjugate vaccine (7PCV). Universal infant 7PCV will prevent pneumococcal diseases and deaths. The potential for its impact to be reduced in the long-term by serotype replacement must be closely monitored. Information concerning disease epidemiology, vaccine efficacy and safety, disease risk perception and national costs may prove useful in discussions with families.
Keywords bacterial vaccines
biological products
immunologic and biological factors
pneumococcal vaccines
vaccines
DOI http://dx.doi.org/10.1111/j.1440-1754.2005.00588.x   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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