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Paraoxonase activity in Greek migrants and Anglo-Celtic persons in the Melbourne collaborative cohort study: relationship to dietary markers

O'Dea, K (2005). Paraoxonase activity in Greek migrants and Anglo-Celtic persons in the Melbourne collaborative cohort study: relationship to dietary markers. European Journal of Nutrition,44(4):223-230.

Document type: Journal Article
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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ISI LOC 000229577700004
Title Paraoxonase activity in Greek migrants and Anglo-Celtic persons in the Melbourne collaborative cohort study: relationship to dietary markers
Author O'Dea, K
Journal Name European Journal of Nutrition
Publication Date 2005
Volume Number 44
Issue Number 4
ISSN 1436-6207   (check CDU catalogue open catalogue search in new window)
Start Page 223
End Page 230
Place of Publication Germany
Publisher Dr. Dietrich Steinkopff Verlag
HERDC Category C1 - Journal Article (DEST)
Abstract Background Greek migrants to Australia have low all-cause and cardiovascular disease (CVD) mortality. This may be partly due to maintenance of a traditional Mediterranean diet and its interaction with CVD risk factors. The enzyme paraoxonase-1 (PON1) is thought to contribute to the anti-atherogenic properties of high density lipoproteins (HDL) by metabolizing lipid peroxides. PON1 activity is subject to modulation by dietary and genetic factors. Aims To determine PON1 activity in Greek migrants and Anglo-Celtic subjects recruited from the Melbourne Collaborative Cohort Study, and its relationship to coronary risk factors and dietary markers. Methods Greek (n = 127) and Anglo-Celtic (n=128) participants in the MCCS were recruited. By design, there were approximately equal numbers of men and women and of diabetic and non-diabetic subjects. Subjects were screened for glucose tolerance, dyslipidaemia, hypertension and coronary heart disease. Plasma markers of diet (carotenoids, retinol, tocopherol, homocysteine) and inflammation (C-reactive protein) were assessed. Serum PON1 activity was determined spectrophotometrically using two substrates: paraoxon (paraoxonase) and phenylacetate (arylesterase). Results PON1 activity was significantly higher in the presence of hyperlipidaemia but otherwise did not vary by ethnicity, presence of coronary heart disease, diabetes, hypertension or smoking. Among subjects with the high activity phenotype (defined by the ratio of paraoxonase:arylesterase activity), paraoxonase activity correlated directly with circulating diet-derived carotenoid concentrations for Greeks, and inversely with homocysteine and C-reactive protein for Anglo-Celtics. No such associations were seen among subjects with the low activity phenotype. Conclusions The data suggest that dietary modulation of atherosclerotic risk may vary according to PON1 phenotype.
 
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