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Analysis of Mycobacterium tuberculosis isolates from treatment failure patients living in East Timor

Kelly, PM, Lumb, R, Pinto, A, da Costa, G, Sarmento, J and Bastian, I (2005). Analysis of Mycobacterium tuberculosis isolates from treatment failure patients living in East Timor. International Journal of Tuberculosis and Lung Disease,9(1):81-86.

Document type: Journal Article
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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ISI LOC 000226181800014
Title Analysis of Mycobacterium tuberculosis isolates from treatment failure patients living in East Timor
Author Kelly, PM
Lumb, R
Pinto, A
da Costa, G
Sarmento, J
Bastian, I
Journal Name International Journal of Tuberculosis and Lung Disease
Publication Date 2005
Volume Number 9
Issue Number 1
ISSN 1027-3719   (check CDU catalogue open catalogue search in new window)
Start Page 81
End Page 86
Place of Publication France
Publisher International Union against Tuberculosis and Lung Disease
HERDC Category C1 - Journal Article (DEST)
Abstract SETTING: In the first 2 years of the East Timor National TB Control Programme, 7960 new patients were treated (2RHZE/6HE) and 224 received a retreatment regimen (2SRHZE/IRHZE/4R(3)H(3)Z(3)E(3)). OBJECTIVE: To determine the nature and extent of drug-resistant tuberculosis (TB) in treatment failure cases in East Timor. METHODS: Sputum specimens from retreatment failure cases were processed and inoculated into a BACTEC MGIT960 tube and onto Lowenstein-Jensen media. Isolates were identified by Ziehl-Neelsen staining, hybridisation with nucleic acid probes and biochemical investigations. Susceptibility testing was performed using the radiometric proportion method. Pyrazinamide testing was performed using the Wayne indirect method. RESULTS: Eighteen patients failed retreatment (0.7% of new cases) and 14 were available for analysis. Mycobactetium tuberculosis was cultured from all specimens, despite considerable transport delays. Nine (64.3%) had multiple drug resistance (MDR-TB) and four (28.6%) had other drug resistance. All MDR-TB isolates were susceptible to amikacin, capreomycin and ethionamide, with most also susceptible to ciprofloxacin and para-aminosalicylic acid (PAS). CONCLUSIONS: An excellent TB control programme has been established in East Timor. If funds are available, East Timor provides an ideal setting for a small-scale DOTS-Plus programme to treat prevalent cases of MDR-TB, and this study could inform the second-line drug regimen.
Keywords tuberculosis
east timor
multidrug resistance
treatment failure
vntr
drug-resistant tuberculosis
retreatment
outcomes
 
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Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator