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Neurological and Cognitive Recovery Following Abstinence from Petrol Sniffing

Cairney, Sheree J., Maruff, P., Burns, Chris B., Currie, Jon and Currie, Bart J. (2005). Neurological and Cognitive Recovery Following Abstinence from Petrol Sniffing. Neuropsychopharmacology,30(5):1019-1027.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 6
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IRMA ID 10240xPUB20
Title Neurological and Cognitive Recovery Following Abstinence from Petrol Sniffing
Author Cairney, Sheree J.
Maruff, P.
Burns, Chris B.
Currie, Jon
Currie, Bart J.
Journal Name Neuropsychopharmacology
Publication Date 2005
Volume Number 30
Issue Number 5
ISSN 0893-133X   (check CDU catalogue open catalogue search in new window)
Start Page 1019
End Page 1027
Total Pages 9
Place of Publication UK
Publisher Nature Publishing Group
Field of Research 1103 - Clinical Sciences
1109 - Neurosciences
1115 - Pharmacology and Pharmaceutical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract Anecdotal observations suggest that neurological impairments associated with petrol (gasoline) sniffing resolve with abstinence, although these effects have not been proven empirically. Severe exposure to leaded petrol may induce a lead encephalopathy that extends beyond any acute intoxication and requires emergency hospital treatment. Previously, in chronic petrol sniffers, we showed neurological, saccadic, and cognitive abnormalities that were more severe in petrol sniffers with a history of hospitalization for lead encephalopathy, and that correlated with blood lead levels and the length of time of sniffing petrol. Ex-petrol sniffers showed a qualitatively similar but quantitatively less severe pattern of impairment. Petrol sniffing was stopped completely in one of the study communities by modifying social, occupational, and recreational opportunities. After 2 years, we obtained biochemical and neurobehavioral (neurological, saccade, and cognitive) data from all available participants of the earlier study including 10 nonsniffers and 29 chronic petrol sniffers, with six of these individuals previously receiving hospital treatment for lead encephalopathy. Here, we report that blood lead was reduced and that neurobehavioral impairments improved, and in many cases normalized completely. The most severe petrol-related neurobehavioral impairment was observed among individuals who had longer histories of abuse and higher blood lead levels, and among petrol sniffers with a history of lead encephalopathy. Those with the greatest extent of neurobehavioral impairment showed the greatest degree of improvement with abstinence, but were less likely to recover completely, This is the first direct evidence that neurological and cognitive impairment from chronic petrol sniffing ameliorates with abstinence and may recover completely.
Keywords petrol
gasoline
inhalant
sniffing
neurological
cognitive
DOI http://dx.doi.org/10.1038/sj.npp.1300682   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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