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Short report: The role and significance of sputum cultures in the diagnosis of melioidosis

Huis in 't Veld, Dina, Wuthiekanun, Vanaporn, Cheng, Allen C., Chierakul, Wirongrong, Chaowagul, Wipada, Brouwer, AnneMarie E., White, Nicholas J., Day, Nicholas P. J. and Peacock, Sharon J. (2005). Short report: The role and significance of sputum cultures in the diagnosis of melioidosis. American Journal of Tropical Medicine and Hygiene,73(4):657-661.

Document type: Journal Article
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Title Short report: The role and significance of sputum cultures in the diagnosis of melioidosis
Author Huis in 't Veld, Dina
Wuthiekanun, Vanaporn
Cheng, Allen C.
Chierakul, Wirongrong
Chaowagul, Wipada
Brouwer, AnneMarie E.
White, Nicholas J.
Day, Nicholas P. J.
Peacock, Sharon J.
Journal Name American Journal of Tropical Medicine and Hygiene
Publication Date 2005
Volume Number 73
Issue Number 4
ISSN 0002-9637   (check CDU catalogue  open catalogue search in new window)
Start Page 657
End Page 661
Place of Publication American Journal of Tropical Medicine
Publisher American Society of Tropical Medicine and Hygiene
HERDC Category C1 - Journal Article (DEST)
Abstract Pneumonia is a common manifestation of melioidosis, the disease caused by Burkholderia pseudomallei. In this study, we defined the prognostic significance of a positive sputum culture. A total of 712 patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani, Thailand, with melioidosis between January 1992 and December 2002 had a sputum culture performed during admission, which was positive for B. pseudomallei in 444 patients (62%). The median duration of sputum positivity was 9 days (range, 1 to 49 days). Sputum cultures were negative in 32% of patients with radiologic changes suggestive of pulmonary involvement. Overall in-hospital mortality was 48%. A positive sputum culture was associated with mortality (adjusted OR 2.8, 95% CI: 1.9, 4.0; P < 0.001). This was independent of renal disease, a prior history of melioidosis, positive blood cultures, and other potential confounders. The presence of B. pseudomallei in the sputum of patients with melioidosis is associated with a poorer prognosis.
Keywords immunofluorescence microscopy
pulmonary melioidosis
laboratory diagnosis
thailand
pseudomallei
northeast
pneumonia
 
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