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Variations in the protective immune response against streptococcal superantigens in populations of different ethnicity

Yang, Lily P. H., Eriksson, Björn, Harrington, Zinta, Curtis, Nigel, Lang, Selwyn, Currie, Bart J., Fraser, John D. and Proft, Thomas (2006). Variations in the protective immune response against streptococcal superantigens in populations of different ethnicity. Medical Microbiology and Immunology,195(1):37-43.

Document type: Journal Article
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IRMA ID 10139xPUB113
Title Variations in the protective immune response against streptococcal superantigens in populations of different ethnicity
Author Yang, Lily P. H.
Eriksson, Björn
Harrington, Zinta
Curtis, Nigel
Lang, Selwyn
Currie, Bart J.
Fraser, John D.
Proft, Thomas
Journal Name Medical Microbiology and Immunology
Publication Date 2006
Volume Number 195
Issue Number 1
ISSN 0300-8584   (check CDU catalogue  open catalogue search in new window)
Start Page 37
End Page 43
Total Pages 7
Place of Publication Germany
Publisher Springer
Field of Research 1107 - Immunology
1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Abstract Superantigens (SAgs) from group A streptococcus (GAS) are potent T cell mitogens, and have been suggested to play a role in severe streptococcal disease. Neutralizing antibodies protect against SAg-mediated disease and their levels should therefore be inversely related to severe streptococcal infection. Neutralizing anti-SAg titers in patients with severe GAS infection and patients without disease were compared in two separate groups. The first group comprised patients with invasive GAS disease from New Zealand European, Maori, and Pacific Island descent. The second group comprised Aboriginal Australian individuals with rheumatic heart disease and/or a past history of acute rheumatic fever. Patients sera were tested for their ability to neutralize T cell mitogenicity of recombinant streptococcal SAgs as a measure of functional SAg-neutralizing antibody concentration. In both studies, no inverse correlation was observed between disease and the level of serum SAg-neutralizing activity. Notably, much higher levels of natural immunity to all streptococcal SAgs were found in New Zealand Maori, New Zealand Pacific Island, and Aboriginal Australian individuals, suggesting a high degree of natural exposure and seroconversion in these groups compared to the New Zealand European cohort. Levels of serum antibodies against SAgs could not be used to predict disease susceptibility in groups with existing high levels of SAg-neutralizing antibodies.
Keywords Group A streptococcus (GAS)
Invasive streptococcal disease
Acute rheumatic fever
Streptococcal superantigen
Neutralizing antibodies
DOI http://dx.doi.org/10.1007/s00430-005-0245-6   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes CDU Research RID# 2006000196
 
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