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Plasmodium vivax genetic diversity: microsatellite length matters

Russell, B, Suwanarusk, R and Lek-Uthai, U (2006). Plasmodium vivax genetic diversity: microsatellite length matters. Trends in Parasitology,22(9):399-401.

Document type: Journal Article
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Title Plasmodium vivax genetic diversity: microsatellite length matters
Author Russell, B
Suwanarusk, R
Lek-Uthai, U
Journal Name Trends in Parasitology
Publication Date 2006
Volume Number 22
Issue Number 9
ISSN 1471-4922   (check CDU catalogue open catalogue search in new window)
Start Page 399
End Page 401
Place of Publication UK
Publisher Elsevier
HERDC Category C1 - Journal Article (DEST)
Abstract The Plasmodium vivax genome is very diverse but h as a relatively low abundance of microsatellites. Leclerc et al. had shown that these di-nucleotide repeats have a low level of polymorphism, suggesting a recent bottleneck event in the evolutionary history of A vivax. By contrast, in a recent paper, Imwong et al. show that there is a very high level of microsatellite diversity. The difference in these results is probably due to the set array lengths chosen by each group. Longer arrays are more diverse than are shorter ones because slippage mutations become exponentially more common with an increase in array length. These studies highlight the need to consider carefully the application and design of studies involving microsatellites.
Keywords chloroquine resistance
human malaria
genome
mutation
loci
DOI http://dx.doi.org/10.1016/j.pt.2006.06.013   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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