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Malaria tolerance - for whom the cell tolls?

Boutlis, Craig, Yeo, and Anstey, Nicholas M. (2006). Malaria tolerance - for whom the cell tolls?. Trends in Parasitology,22(8):371-377.

Document type: Journal Article
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IRMA ID 10247xPUB11
Title Malaria tolerance - for whom the cell tolls?
Author Boutlis, Craig
Anstey, Nicholas M.
Journal Name Trends in Parasitology
Publication Date 2006
Volume Number 22
Issue Number 8
ISSN 1471-4922   (check CDU catalogue open catalogue search in new window)
Start Page 371
End Page 377
Total Pages 7
Place of Publication UK
Publisher Elsevier Ltd
Field of Research 0605 - Microbiology
0707 - Veterinary Sciences
1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract How is it that individuals exposed to intense malaria transmission can tolerate the presence of malaria parasites in their blood at levels that would produce fever in others? In light of evidence discounting a role for nitric oxide or antibodies to plasmodial glycosylphosphatidylinositols in maintaining this tolerant state, refractoriness to toxin-induced Toll-like receptor-mediated signalling has emerged as a likely explanation that links malarial and bacterial endotoxin tolerance. Understanding the mechanisms underlying tolerance and the potential for cross-tolerization has significant implications for. understanding the potential for antitoxic vaccine strategies, as well as interactions between different malaria species and between malaria and other human parasites.
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Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator