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Group A streptococcal infections of the skin: molecular advances but limited therapeutic progress

Currie, Bart J. (2006). Group A streptococcal infections of the skin: molecular advances but limited therapeutic progress. Current Opinion in Infectious Diseases,19(2):132-138.

Document type: Journal Article
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IRMA ID 10139xPUB90
Title Group A streptococcal infections of the skin: molecular advances but limited therapeutic progress
Author Currie, Bart J.
Journal Name Current Opinion in Infectious Diseases
Publication Date 2006
Volume Number 19
Issue Number 2
ISSN 0951-7375   (check CDU catalogue open catalogue search in new window)
Start Page 132
End Page 138
Total Pages 7
Place of Publication US
Publisher Lippincott Williams & Wilkins
HERDC Category C1 - Journal Article (DEST)
Abstract Purpose of review With the sequencing of several Streptococcus pyogenes (group A Streptococcus) genomes have come major advances in understanding the pathogenesis of group A Streptococcus-associated diseases. This review focuses on group A Streptococcus skin infections and summarizes data published in the English language medical literature in 2004 and 2005. Recent findings Group A Streptococcus shows enormous and evolving molecular diversity driven by horizontal transmission between group A Streptococcus strains and between group A Streptococcus and other streptococci. Acquisition of prophages accounts for much of the diversity, conferring both virulence through phage-associated virulence factors and increased bacterial survival against host defences. Studies of group A Streptococcus isolates outside the US also question the generalizability -of classic group A Streptococcus M serotype associations with specific disease entities such as acute rheumatic fever and necrotizing fasciitis. The distinction between throat and skin group A Streptococcus has become blurred. Although there have been few advances in treatment of group A Streptococcus skin infections, developments towards group A Streptococcus vaccines are promising. Summary The diversity of group A Streptococcus remains a challenge for vaccine development. As acute rheumatic fever and streptococcal pyoderma occur predominantly in disadvantaged populations, international funding support will be necessary for any group A Streptococcus vaccine to have a sustained impact on the global burden of disease.
Keywords acute rheumatic fever
group a streptococcus
necrotizing fasciitis
poststreptococcal glomerulonephritis
streptococcus pyogenes
acute rheumatic-fever
fibronectin-binding protein
intravenous polyspecific immunoglobulin
soft-tissue infections
necrotizing fasciitis
emm types
invasive infection
virulence factor
genome sequence
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Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator