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Indirect hemagglutination assay in patients with melioidosis in northern Australia

Cheng, Allen C., O'Brien, Mathew, Freeman, Kevin, Lum, Gary and Currie, Bart J. (2006). Indirect hemagglutination assay in patients with melioidosis in northern Australia. American Journal of Tropical Medicine and Hygiene,74(2):330-334.

Document type: Journal Article
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IRMA ID 10139xPUB126
Title Indirect hemagglutination assay in patients with melioidosis in northern Australia
Author Cheng, Allen C.
O'Brien, Mathew
Freeman, Kevin
Lum, Gary
Currie, Bart J.
Journal Name American Journal of Tropical Medicine and Hygiene
Publication Date 2006
Volume Number 74
Issue Number 2
ISSN 0002-9637   (check CDU catalogue  open catalogue search in new window)
Start Page 330
End Page 334
Total Pages 5
Place of Publication US
Publisher The American Society of Tropical Medicine and Hygiene
HERDC Category C1 - Journal Article (DEST)
Abstract Melioidosis is caused by the saprophytic organism Burkholderia pseudomallei. The use of the indirect hemagglutination assay (I HA) has found widespread use in areas endemic for this disease. Using this assay, we explored the serologic profile of 275 patients with culture-confirmed melioidosis in the Northern Territory of Australia. Based on a threshold titer of 1:40. the sensitivity of the IHA on admission was 56%. Female patients, those with positive blood cultures, and those with pneumonia independently predicted a negative IHA result. Most patients (68%) with negative admission IHA titers subsequently seroconverted. Most patients (92%) with positive admission IHA titers had persistently positive IHA titers. Relapses were not observed in 36 patients who had a negative IHA at least I month after admission, irrespective of initial admission IHA. The IHA has limited utility as a diagnostic test for acute disease, and most patients subsequently have persistently positive titers after recovery from illness.
Keywords linked-immunosorbent-assay
burkholderia-pseudomallei
diagnostic-value
immune-response
area
epidemiology
reactivation
antibodies
endemicity
thailand
Additional Notes 3053 (Journal)
 
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Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator