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Identification of ABC transporters in Sarcoptes scabiei

Mounsey, Kate, Holt, Deborah, Mccarthy, J. and Walton, S. (2006). Identification of ABC transporters in Sarcoptes scabiei. Parasitology (Cambridge),132(6):883-892.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 13 times in Scopus Article | Citations

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IRMA ID 10245xPUB2
Title Identification of ABC transporters in Sarcoptes scabiei
Author Mounsey, Kate
Holt, Deborah
Mccarthy, J.
Walton, S.
Journal Name Parasitology (Cambridge)
Publication Date 2006
Volume Number 132
Issue Number 6
ISSN 0031-1820   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-33646750115
Start Page 883
End Page 892
Total Pages 10
Place of Publication UK
Publisher Cambridge University Press
Field of Research 1108 - Medical Microbiology
0605 - Microbiology
0707 - Veterinary Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract We have identified and partially sequenced 8 ABC transporters from an EST dataset of Sarcoptes scabiei var. hominis, the causative agent of scabies. Analysis confirmed that most of the known ABC subfamilies are represented in the EST dataset including several members of the multidrug resistance protein subfamily (ABC-C). Although P-glycoprotein (ABC-B) sequences were not found in the EST dataset, a partial P-glycoprotein sequence was subsequently obtained using a degenerate PCR strategy and library screening. Thus a total of 9 potential S. scabiei ABC transporters representing the subfamilies A, B, C, E, F and H have been identified. Ivermectin is currently used in the treatment of hyper-infested (crusted) scabies, and has also been identified as a potentially effective acaricide for mass treatment programmes in scabies-endemic communities. The observation of clinical and in vitro ivermectin resistance in 2 crusted scabies patients who received multiple treatments has raised serious concerns regarding the sustainability of such programmes. One possible mechanism for ivermectin resistance is through ABC transporters such as P-glycoprotein. This work forms an important foundation for further studies to elucidate the potential role of ABC transporters in ivermectin resistance of S. scabiei.
Keywords Sarcoptes scabiei
ivermectin resistance
ABC transporter
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