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A community-based TB drug susceptibility study in Mimika District, Papua Province, Indonesia

Kelly, P., Ardian, M., Waramori, G., Anstey, Nicholas M., Syahrial, H., Tjitra, E., Bastian, I., Maguire, Graeme and Lumb, R. (2006). A community-based TB drug susceptibility study in Mimika District, Papua Province, Indonesia. International Journal of Tuberculosis and Lung Disease,10(2):167-171.

Document type: Journal Article
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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ISI LOC 000235232600009
IRMA ID 10002xPUB37
Title A community-based TB drug susceptibility study in Mimika District, Papua Province, Indonesia
Author Kelly, P.
Ardian, M.
Waramori, G.
Anstey, Nicholas M.
Syahrial, H.
Tjitra, E.
Bastian, I.
Maguire, Graeme
Lumb, R.
Journal Name International Journal of Tuberculosis and Lung Disease
Publication Date 2006
Volume Number 10
Issue Number 2
ISSN 1027-3719   (check CDU catalogue open catalogue search in new window)
Start Page 167
End Page 171
Total Pages 5
Place of Publication France
Publisher International Union Against Tuberculosis and Lung Disease
Field of Research 1102 - Cardiovascular Medicine and Haematology
HERDC Category C1 - Journal Article (DEST)
Abstract SETTING: A district level tuberculosis (TB) control programme in Papua Province, Indonesia.

OBJECTIVE: To determine the nature and extent of drug-resistant TB in newly diagnosed sputum smear-positive patients.

METHODS: Sputum was collected from previously untreated smear-positive pulmonary TB patients diagnosed in the district over a 10-month period. Sputum specimens were processed and inoculated into a BACTEC MGIT960 tube. Isolates were identified by Ziehl-Neelsen staining, hybridisation with nucleic acid probes and biochemical investigations. Susceptibility testing was performed using the radiometric proportion method. Pyrazinamide testing was performed using the Wayne indirect method.

RESULTS: One hundred and seven patients had sputum sent to a reference laboratory; 101 (94.4%) were culture-positive for Mycobacterium tuberculosis, with 87 (86.1%) fully sensitive to first-line anti-tuberculosis drugs. Two per cent were multidrug-resistant (MDR-TB) and 12 (11.9%) had other drug resistance. Each of the MDR-TB isolates was susceptible to amikacin, capreomycin, ciprofloxacin and para-aminosalicylic acid (PAS), but were resistant to rifabutin. One isolate was also resistant to ethionamide.

CONCLUSIONS: MDR-TB is present in Indonesia but is not a major problem for TB control in this district. Generalisability to other districts in Indonesia, particularly large urban areas, needs to be confirmed by future studies.
Keywords tuberculosis
multi-drug resistance
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