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Can a management pathway for chronic cough in children improve clinical outcomes: protocol for a multicentre evaluation

Chang, Anne B., Robertson, C. F., van Asperen, Peter P., Glasgow, N. J., Masters, Ian B., Mellis, C. M., Landau, L. I., Teoh, Laurel and Morris, Peter S. (2010). Can a management pathway for chronic cough in children improve clinical outcomes: protocol for a multicentre evaluation. Trials,11:103-109.

Document type: Journal Article
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IRMA ID 81704288xPUB300
Title Can a management pathway for chronic cough in children improve clinical outcomes: protocol for a multicentre evaluation
Author Chang, Anne B.
Robertson, C. F.
van Asperen, Peter P.
Glasgow, N. J.
Masters, Ian B.
Mellis, C. M.
Landau, L. I.
Teoh, Laurel
Morris, Peter S.
Journal Name Trials
Publication Date 2010
Volume Number 11
ISSN 1745-6215   (check CDU catalogue open catalogue search in new window)
Start Page 103
End Page 109
Total Pages 7
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Background: Chronic cough is common and is associated with significant economic and human costs. While cough can be a problematic symptom without serious consequences, it could also reflect a serious underlying illness. Evidence shows that the management of chronic cough in children needs to be improved. Our study tests
the hypothesis that the management of chronic cough in children with an evidence-based management pathway is feasible and reliable, and improves clinical outcomes.

Methods/Design: We are conducting a multicentre randomised controlled trial based in respiratory clinics in 5 major Australian cities. Children (n = 250) fulfilling inclusion criteria (new patients with chronic cough) are randomised (allocation concealed) to the standardised clinical management pathway (specialist starts clinical pathway within 2 weeks) or usual care (existing care until review by specialist at 6 weeks). Cough diary, coughspecific quality of life (QOL) and generic QOL are collected at baseline and at 6, 10, 14, 26, and 52 weeks. Children are followed-up for 6 months after diagnosis and cough resolution (with at least monthly contact from study
nurses). A random sample from each site will be independently examined to determine adherence to the pathway. Primary outcomes are group differences in QOL and proportion of children that are cough free at week 6.

Discussion: The clinical management pathway is based on data from Cochrane Reviews combined with collective clinical experience (250 doctor years). This study will provide additional evidence on the optimal management of chronic cough in children.
Keywords chronic cough
children
DOI http://dx.doi.org/10.1186/1745-6215-11-103   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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