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Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes

Isbister, Geoffrey K., Murray, Linsay, John, Sally, Hackett, L. Peter, Haider, Tedo, O'Mullane, Phebe, Gosselin, Sophie and Daly, Frank (2006). Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes. Medical Journal of Australia,184(7):354-356.

Document type: Journal Article
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Title Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes
Author Isbister, Geoffrey K.
Murray, Linsay
John, Sally
Hackett, L. Peter
Haider, Tedo
O'Mullane, Phebe
Gosselin, Sophie
Daly, Frank
Journal Name Medical Journal of Australia
Publication Date 2006
Volume Number 184
Issue Number 7
ISSN 0025-729X   (check CDU catalogue open catalogue search in new window)
Start Page 354
End Page 356
Total Pages 3
Place of Publication Australia
Publisher Australasian Medical Publishing Company Pty. Ltd.
HERDC Category C2 - Journal Article - Other contributions to refereed journal (internal)
Abstract Although clinical trials of the antipsychotic amisulpride revealed no cardiac adverse effects, four patients with severe cardiac toxicity after overdose were reported to Australian poisons information centres in 2004-2005. All four had QT prolongation over 500 ms, two had rate-dependent bundle branch block, two developed torsades de pointes, and one died after cardiac arrest. Pending further studies, we recommend electrocardiogram assessment until at least 16 h after amisulpride overdose and, if QT interval is prolonged, cardiac monitoring until the patient is clinically well and conduction intervals are normal.
Keywords human-plasma
citalopram
safety
toxicity
Description for Link Link to published version
URL https://www.mja.com.au/journal/2006/184/7/amisulpride-deliberate-self-poisoning-causing-severe-cardiac-toxicity-including
 
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Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator