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Fibrinogen and associated risk factors in a high-risk population: urban Indigenous Australians, the druid study

Maple-Brown, Louise J, Cunningham, Joan, Nandi, Nirjhar, Hodge, Allison and O'Dea, Kerin (2010). Fibrinogen and associated risk factors in a high-risk population: urban Indigenous Australians, the druid study. Cardiovascular Diabetology,9(69):1-7.

Document type: Journal Article
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NHMRC Grant No. 236207
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Title Fibrinogen and associated risk factors in a high-risk population: urban Indigenous Australians, the druid study
Author Maple-Brown, Louise J
Cunningham, Joan
Nandi, Nirjhar
Hodge, Allison
O'Dea, Kerin
Journal Name Cardiovascular Diabetology
Publication Date 2010
Volume Number 9
Issue Number 69
ISSN 1475-2840   (check CDU catalogue  open catalogue search in new window)
Start Page 1
End Page 7
Total Pages 7
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
Abstract Background: Epidemiological evidence suggests that fibrinogen and CRP are associated with coronary heart disease risk. High CRP in Indigenous Australians has been reported in previous studies including our ‘Diabetes and Related diseases in Urban Indigenous population in Darwin region’ (DRUID) Study. We studied levels of fibrinogen and its cross-sectional relationship with traditional and non-traditional cardiovascular risk factors in an urban Indigenous Australian cohort.

Methods:
Fibrinogen data were available from 287 males and 628 females (aged ≥ 15 years) from the DRUID study. Analysis was performed for associations with the following risk factors: diabetes, HbA1c, age, BMI, waist circumference, waist-hip ratio, total cholesterol, triglyceride, HDL cholesterol, C-reactive protein, homocysteine,
blood pressure, heart rate, urine ACR, smoking status, alcohol abstinence.

Results:
Fibrinogen generally increased with age in both genders; levels by age group were higher than those previously reported in other populations, including Native Americans. Fibrinogen was higher in those with than without diabetes (4.24 vs 3.56 g/L, p < 0.001). After adjusting for age and sex, the following were significantly associated with fibrinogen: BMI, waist, waist-hip ratio, systolic blood pressure, heart rate, fasting triglycerides, HDL cholesterol, HbA1c, CRP, ACR and alcohol abstinence. On multivariate regression (age and sex-adjusted) CRP and HbA1c were significant independent predictors of fibrinogen, explaining 27% of its variance; CRP alone explained 25% of fibrinogen variance. On factor analysis, both CRP and fibrinogen clustered with obesity in women (this factor explained 20% of variance); but in men, CRP clustered with obesity (factor explained 18% of variance) whilst fibrinogen clustered with HbA1c and urine ACR (factor explained 13% of variance).

Conclusions:
Fibrinogen is associated with traditional and non-traditional cardiovascular risk factors in this urban Indigenous cohort and may be a useful biomarker of CVD in this high-risk population. The apparent different associations of fibrinogen with cardiovascular disease risk markers in men and women should be explored further.
Keywords fibrinogen
Diabetes and Related diseases in Urban Indigenous population in Darwin region’ (DRUID) Study
Indigenous Australians
coronary heart disease risk
cardiovascular risk factors
DOI http://dx.doi.org/10.1186/1475-2840-9-69   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Created: Wed, 10 Oct 2012, 15:43:07 CST by Teresa Haendel