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Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum

Karyana, Muhammad, Burdarm, Lenny, Yeung, Shunmay, Kenangalem, Enny, Wariker, Noah, Maristela, Rilia, Umana, Ketut Gde, Vemuri, Siva Ram, Okoseray, Maurits J., Penttinen, Pasi M. P., Ebsworth, Peter, Sugiarto, Paulus, Anstey, Nicholas M., Tjitra, Emiliana and Price, Ric N. (2008). Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum. Malaria Journal,7:148-157.

Document type: Journal Article
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IRMA ID 75039815xPUB135
Title Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum
Author Karyana, Muhammad
Burdarm, Lenny
Yeung, Shunmay
Kenangalem, Enny
Wariker, Noah
Maristela, Rilia
Umana, Ketut Gde
Vemuri, Siva Ram
Okoseray, Maurits J.
Penttinen, Pasi M. P.
Ebsworth, Peter
Sugiarto, Paulus
Anstey, Nicholas M.
Tjitra, Emiliana
Price, Ric N.
Journal Name Malaria Journal
Publication Date 2008
Volume Number 7
ISSN 1475-2875   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-50049092433
Start Page 148
End Page 157
Total Pages 10
Place of Publication London, U.K.
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DEST)
Abstract Background
Multidrug resistance has emerged to both Plasmodium vivax and Plasmodium falciparum and yet the comparative epidemiology of these infections is poorly defined.

Methods

All laboratory-confirmed episodes of malaria in Timika, Papua, Indonesia, presenting to community primary care clinics and an inpatient facility were reviewed over a two-year period. In addition information was gathered from a house-to-house survey to quantify the prevalence of malaria and treatment-seeking behaviour of people with fever.

Results
Between January 2004 and December 2005, 99,158 laboratory-confirmed episodes of malaria were reported, of which 58% (57,938) were attributable to P. falciparum and 37% (36,471) to P. vivax. Malaria was most likely to be attributable to pure P. vivax in children under one year of age (55% 2,684/4,889). In the household survey, the prevalence of asexual parasitaemia was 7.5% (290/3,890) for P. falciparum and 6.4% (248/3,890) for P. vivax. The prevalence of P. falciparum infection peaked in young adults aged 15–25 years (9.8% 69/707), compared to P. vivax infection which peaked in children aged 1 to 4 years (9.5% 61/642). Overall 35% (1,813/5,255) of people questioned reported a febrile episode in the preceding month. Of the 60% of people who were estimated to have had malaria, only 39% would have been detected by the surveillance network. The overall incidence of malaria was therefore estimated as 876 per 1,000 per year (Range: 711–906).

Conclusion
In this region of multidrug-resistant P. vivax and P. falciparum, both species are associated with substantial morbidity, but with significant differences in the age-related risk of infection.

Keywords Plasmodium vivax
Plasmodium falciparum
Papua Indonesia
malaria morbidity
multidrug resistant
DOI http://dx.doi.org/10.1186/1475-2875-7-148   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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