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The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

Lee, Sue J., Stepniewska, Kasia, Anstey, Nicholas M., Ashley, Elizabeth, Barnes, Karen, Binh, Tran Quang, D`Alessandro, Umberto, Day, Nicholas P. J., Vries, Peter J. de, Dorsey, Grant, Guthmann, Jean-Paul, Mayxay, Mayfong, Newton, Paul N., Nosten, Francois, Olliaro, Piero, Osario, Lyda, Pinoges, Loretxu, Price, Ric N., Rowland, Mark, White, Nicholas J. and et al. (2008). The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria. Malaria Journal,7:149-152.

Document type: Journal Article
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IRMA ID 75039815xPUB223
Title The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria
Author Lee, Sue J.
Stepniewska, Kasia
Anstey, Nicholas M.
Ashley, Elizabeth
Barnes, Karen
Binh, Tran Quang
D`Alessandro, Umberto
Day, Nicholas P. J.
Vries, Peter J. de
Dorsey, Grant
Guthmann, Jean-Paul
Mayxay, Mayfong
Newton, Paul N.
Nosten, Francois
Olliaro, Piero
Osario, Lyda
Pinoges, Loretxu
Price, Ric N.
Rowland, Mark
White, Nicholas J.
et al.
Journal Name Malaria Journal
Publication Date 2008
Volume Number 7
ISSN 1475-2875   (check CDU catalogue  open catalogue search in new window)
Start Page 149
End Page 152
Total Pages 4
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
Abstract Background
Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other.

Methods

Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion.

Results

A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (± SD) of -0.69 (± 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients).

Conclusion

Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid.

Keywords haemoglobin concentration
haematocrit
Plasmodium falciparum
malaria
DOI http://dx.doi.org/10.1186/1475-2875-7-149   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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