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Field evaluation of a rapid immunochromatographic dipstick test for the diagnosis of cholera in a high-risk population

Wang, Xuan-Yi, Ansaruzzaman, M., Vaz, Raul, Mondlane, Catarina, Lucas, Marcelino E.S., von Seidlein, Lorenz, Deen, Jacqueline L., Ampuero, Sonia, Puri, Mahesh, Park, Taesung, Nair, G. B., Clemens, John D., Chaignat, Claire-Lise, Rajerison, Minoarisoa, Nato, Farida and Fournier, Jean-Michel (2006). Field evaluation of a rapid immunochromatographic dipstick test for the diagnosis of cholera in a high-risk population. BMC Infectious Diseases,6(1):17-23.

Document type: Journal Article
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Title Field evaluation of a rapid immunochromatographic dipstick test for the diagnosis of cholera in a high-risk population
Author Wang, Xuan-Yi
Ansaruzzaman, M.
Vaz, Raul
Mondlane, Catarina
Lucas, Marcelino E.S.
von Seidlein, Lorenz
Deen, Jacqueline L.
Ampuero, Sonia
Puri, Mahesh
Park, Taesung
Nair, G. B.
Clemens, John D.
Chaignat, Claire-Lise
Rajerison, Minoarisoa
Nato, Farida
Fournier, Jean-Michel
Journal Name BMC Infectious Diseases
Publication Date 2006
Volume Number 6
Issue Number 1
ISSN 1471-2334   (check CDU catalogue  open catalogue search in new window)
Start Page 17
End Page 23
Total Pages 7
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
Abstract Background
Early detection of cholera outbreaks is crucial for the implementation of the most appropriate control strategies.

Methods

The performance of an immunochromatographic dipstick test (Institute Pasteur, Paris, France) specific for Vibrio cholerae O1 was evaluated in a prospective study in Beira, Mozambique, during the 2004 cholera season (January-May). Fecal specimens were collected from 391 patients with acute watery nonbloody diarrhea and tested by dipstick and conventional culture.

Results

The overall sensitivity and specificity of the rapid test compared to culture were 95% (95% confidence interval [CI]: 91%–99%) and 89% (95% CI: 86%–93%), respectively. After stratification by type of sample (rectal swab/bulk stool) and severity of diarrhea, the sensitivity ranged between 85% and 98% and specificity between 77% and 97%.

Conclusion

This one-step dipstick test performed well in the diagnosis of V. cholerae O1 in a setting with seasonal outbreaks where rapid tests are most urgently needed.
Keywords detection of cholera outbreaks
cholera
control strategies
DOI http://dx.doi.org/10.1186/1471-2334-6-17   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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Created: Mon, 26 Nov 2012, 16:08:27 CST by Teresa Haendel