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Increased arterial stiffness in remote Indigenous Australians with high risk of cardiovascular disease

Maple-Brown, Louise, Piers, Leonard, O'Rourke, Michael, Celermajer, David and O'Dea, Kerin (2007). Increased arterial stiffness in remote Indigenous Australians with high risk of cardiovascular disease. Journal of Hypertension,25(3):585-591.

Document type: Journal Article
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IRMA ID 10426xPUB13
Title Increased arterial stiffness in remote Indigenous Australians with high risk of cardiovascular disease
Author Maple-Brown, Louise
Piers, Leonard
O'Rourke, Michael
Celermajer, David
O'Dea, Kerin
Journal Name Journal of Hypertension
Publication Date 2007
Volume Number 25
Issue Number 3
ISSN 0263-6352   (check CDU catalogue open catalogue search in new window)
Start Page 585
End Page 591
Total Pages 7
Place of Publication US
Publisher Lippincott Williams and Wilkins
HERDC Category C1 - Journal Article (DEST)
Abstract Objective
To assess central and peripheral arterial stiffness in Indigenous and European Australians with and without type 2 diabetes using applanation tonometry to obtain the augmentation index (AI) and pulse wave velocity (PWV).

Methods

AI was assessed in 162 Indigenous Australians (60 with type 2 diabetes) participating in a population-based study and 121 Australians of European ancestry (38 with diabetes) of similar age and sex. PWV was assessed in a subgroup: n = 62 indigenous, n = 118 European participants. Results The indigenous group had higher Al than the European group [mean (SD) 32 (12) versus 24 (12)%, P < 0.0001] and carotid-femoral PWV [8.4 (1.8) versus 7.1 (2.2) ms(-1), P < 0.0001]. There were no significant differences between groups regarding blood pressure and total cholesterol; however, indigenous individuals had higher fasting glucose, insulin, haemoglobin A1c, triglycerides, waist circumference (despite lower body mass index), and a higher prevalence of cigarette smoking. Fifty-five per cent of the variance in Al was explained on multiple regression analysis by age, sex, indigenous participant, heart rate, mean arterial pressure, height, triglycerides and waist circumference. Age, indigenous participant, heart rate, mean arterial pressure and antihypertensive medication explained 56% of the variance in PWV. Variables of the metabolic syndrome and smoking, C-reactive protein (CRIP), homocysteine and heart rate clustered with indigenous status on factor analysis.

Conclusions
Indigenous Australians have higher indices of peripheral and central arterial stiffness than European Australians of similar age and sex. Factor analysis revealed that metabolic syndrome variables, smoking, CRP, homocysteine and heart rate clustered with 'indigenous participant' and may explain increased arterial stiffness in this group.
Keywords Aboriginal
arterial stiffness
augmentation index
central obesity
pulse wave velocity
type 2 diabetes
pulse-wave velocity
diabetes-mellitus
aortic stiffness
insulin concentrations
renal-failure
heart-rate
pressure
glucose
gender
DOI http://dx.doi.org/10.1097/HJH.0b013e328011f766   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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