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Melioidosis in a rural community of Western Province, Papua New Guinea

Warner, Jeffrey M., Pelowa, D. B., Currie, Bart J. and Hirst, R. G. (2007). Melioidosis in a rural community of Western Province, Papua New Guinea. Royal Society of Tropical Medicine and Hygiene. Transactions,101(8):809-813.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 11
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IRMA ID 10139xPUB92
Title Melioidosis in a rural community of Western Province, Papua New Guinea
Author Warner, Jeffrey M.
Pelowa, D. B.
Currie, Bart J.
Hirst, R. G.
Journal Name Royal Society of Tropical Medicine and Hygiene. Transactions
Publication Date 2007
Volume Number 101
Issue Number 8
ISSN 0035-9203   (check CDU catalogue open catalogue search in new window)
Start Page 809
End Page 813
Total Pages 5
Place of Publication United Kingdom
Publisher Oxford University Press
Field of Research 1117 - Public Health and Health Services
1108 - Medical Microbiology
0605 - Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract A prospective study was conducted to determine the significance of melioidosis in the Balimo district of Western Province, Papua New Guinea. During 1998, after the establishment of laboratory procedures and increasing tocal. clinical. awareness, the disease was found in 1.8% (95% Cl 0.37-5.1%) of individuals presenting with fever refractory to standard treatment. The clinical incidence was 20.0 per 100000 population (95% Cl 12.2-30.9). The median age of culture-confirmed cases was 9.5 years (interquartile range 8.3-14.8 years). The sero-prevalence of 747 community children in the region tested was 8.2% (95% Cl 6.2-10.4%). Most individuals presented during the rainy season with a febrile disease refractory to standard treatment, sometimes mimicking tuberculosis. Some family clustering was apparent. AIL patients with bacteraemic melioidosis died, but treatment with the available conventional therapies of chloramphenicol, co-trimoxazole or doxycycline resulted in survival and cure in six patients with subacute/localised melioidosis. Further studies are needed to ascertain the local epidemiology and why children appear particularly at risk, as well as to establish the true extent of melioidosis in Papua New Guinea.
Keywords Melioidosis
Burkholderia pseudomallei
Papua New Guinea
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