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World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria

Plowe, Christopher V., Roper, Cally, Barnwell, John W., Happi, Christian T., Joshi, Hema H., Mbacham, Wilfred, Meshnick, Steven R., Mugittu, Kefas, Naidoo, Inbarani, Price, Ric N., Shafer, Robert W., Sibley, Carol H., Sutherland, Colin J., Zimmerman, Peter A. and Rosenthal, Philip J. (2007). World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria. Malaria journal,6(1 - Article No. 121):121-130.

Document type: Journal Article
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IRMA ID 10202xPUB31
Title World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria
Author Plowe, Christopher V.
Roper, Cally
Barnwell, John W.
Happi, Christian T.
Joshi, Hema H.
Mbacham, Wilfred
Meshnick, Steven R.
Mugittu, Kefas
Naidoo, Inbarani
Price, Ric N.
Shafer, Robert W.
Sibley, Carol H.
Sutherland, Colin J.
Zimmerman, Peter A.
Rosenthal, Philip J.
Journal Name Malaria journal
Publication Date 2007
Volume Number 6
Issue Number 1 - Article No. 121
ISSN 1475-2875   (check CDU catalogue open catalogue search in new window)
Start Page 121
End Page 130
Total Pages 10
Place of Publication United Kingdom
Publisher BioMed Central Ltd
Field of Research 1503 - Business and Management
HERDC Category C1 - Journal Article (DEST)
Abstract Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is scattered in disparate databases with no linkage to the clinical, in vitro and pharmacokinetic data that are needed to relate the genetic data to relevant phenotypes. The ongoing replacement of older monotherapies for malaria by new, more effective combination therapies presents an opportunity to create an open access database that brings together standardized data on molecular markers of drug resistant malaria from around the world. This paper presents a rationale for creating a global database of molecular markers for drug resistant malaria and for linking it to similar databases containing results from clinical trials of drug efficacy, in vitro studies of drug susceptibility, and pharmacokinetic studies of antimalarial drugs, in a World Antimalarial Resistance Network (WARN). This database will be a global resource, guiding the selection of first line drugs for treating uncomplicated malaria, for preventing malaria in travelers and for intermittent preventive treatment of malaria in pregnant women, infants and other vulnerable groups. Perhaps most important, a global database for molecular markers of drug resistant malaria will accelerate the identification and validation of markers for resistance to artemisinin-based combination therapies and, thereby, potentially prolong the useful therapeutic lives of these important new drugs.
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