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A Horizontal gene transfer event defines two distinct groups within Burkholderia pseudomallei that have dissimilar geographic distributions

Tuanyok, Apichai, Auerbach, Raymond K., Brettin, Thomas S., Bruce, David C., Munk, A. Christine, Detter, J. Chris, Pearson, Talima, Hornstra, Heidie, Sermswan, Rasana W., Wuthiekanun, Vanaporn, Peacock, Sharon J., Currie, Bart J., Keim, Paul and Wagner, David M. (2007). A Horizontal gene transfer event defines two distinct groups within Burkholderia pseudomallei that have dissimilar geographic distributions. Journal of Bacteriology,189(24):9044-9049.

Document type: Journal Article
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Title A Horizontal gene transfer event defines two distinct groups within Burkholderia pseudomallei that have dissimilar geographic distributions
Author Tuanyok, Apichai
Auerbach, Raymond K.
Brettin, Thomas S.
Bruce, David C.
Munk, A. Christine
Detter, J. Chris
Pearson, Talima
Hornstra, Heidie
Sermswan, Rasana W.
Wuthiekanun, Vanaporn
Peacock, Sharon J.
Currie, Bart J.
Keim, Paul
Wagner, David M.
Journal Name Journal of Bacteriology
Publication Date 2007
Volume Number 189
Issue Number 24
ISSN 0021-9193   (check CDU catalogue open catalogue search in new window)
Start Page 9044
End Page 9049
Total Pages 6
Place of Publication Washington, United States
Publisher American Society for Microbiology
Field of Research 0605 - Microbiology
1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Burkholderia pseudomallei is the etiologic agent of melioidosis. Many disease manifestations are associated with melioidosis, and the mechanisms causing this variation are unknown; genomic differences among strains offer one explanation. We compared the genome sequences of two strains of B. pseudomallei: the original reference strain K96243 from Thailand and strain MSHR305 from Australia. We identified a variable homologous region between the two strains. This region was previously identified in comparisons of the genome of B. pseudomallei strain K96243 with the genome of strain E264 from the closely related B. thailandensis. In that comparison, K96243 was shown to possess a horizontally acquired Yersinia-like fimbrial (YLF) gene cluster. Here, we show that the homologous genomic region in B. pseudomallei strain 305 is similar to that previously identified in B. thailandensis strain E264. We have named this region in B. pseudomallei strain 305 the B. thailandensis-like flagellum and chemotaxis (BTFC) gene cluster. We screened for these different genomic components across additional genome sequences and 571 B. pseudomallei DNA extracts obtained from regions of endemicity. These alternate genomic states define two distinct groups within B. pseudomallei: all strains contained either the BTFC gene cluster (group BTFC) or the YLF gene cluster (group YLF). These two groups have distinct geographic distributions: group BTFC is dominant in Australia, and group YLF is dominant in Thailand and elsewhere. In addition, clinical isolates are more likely to belong to group YLF, whereas environmental isolates are more likely to belong to group BTFC. These groups should be further characterized in an animal model.
DOI http://dx.doi.org/10.1128/JB.01264-07   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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