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Short report: Electrocardiographic safety evaluation of dihydroartemisinin-piperaquine in the treatment of uncomplicated falciparum malaria

Mytton, OT, Ashley, EA, Peto, L, Price, RN, La, Y, Hae, R, Singhasivanon, P, White, N. and Nosten, F (2007). Short report: Electrocardiographic safety evaluation of dihydroartemisinin-piperaquine in the treatment of uncomplicated falciparum malaria. American Journal of Tropical Medicine and Hygiene,77(3):447-450.

Document type: Journal Article
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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ISI LOC 000249312200008
Title Short report: Electrocardiographic safety evaluation of dihydroartemisinin-piperaquine in the treatment of uncomplicated falciparum malaria
Author Mytton, OT
Ashley, EA
Peto, L
Price, RN
La, Y
Hae, R
Singhasivanon, P
White, N.
Nosten, F
Journal Name American Journal of Tropical Medicine and Hygiene
Publication Date 2007
Volume Number 77
Issue Number 3
ISSN 0002-9637   (check CDU catalogue open catalogue search in new window)
Start Page 447
End Page 450
Place of Publication United states of America
Publisher The American Society of Tropical Medicine and Hygiene
HERDC Category C1 - Journal Article (DEST)
Abstract Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical trials, data on cardiotoxicity are limited. In two randomized controlled trials in Thailand, 56 patients had ECGs performed before treatment, 4 hours after the first dose, and 4 hours after the last close. The mean (95% CI) changes in QTc interval (Bazett's correction) were 2 (-6 to 9) ms and 14 (7 to 21) ms, respectively. These small changes on the third day of treatment are similar to those observed elsewhere in the convalescent phase following antimalarial treatment with drugs known to have no cardiac effects and are therefore likely to result from recovery from acute malaria and not the treatment given. At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram.
Keywords ANTIMALARIAL TREATMENT
QT PROLONGATION
NO EVIDENCE
CARDIOTOXICITY
HALOFANTRINE
ARTEMETHER
CHILDREN
QUININE
COMBINATION
QUINIDINE
 
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Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator