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Prevention of community-acquired pneumonia among a cohort of hospitalized elderly: Benefit due to influenza and pneumococcal vaccination not demonstrated

Skull, Susan A., Andrews, Ross M., Byrnes, Giselle, Kelly, H., Nolan, T., Brown, G. and Campbell, D. (2007). Prevention of community-acquired pneumonia among a cohort of hospitalized elderly: Benefit due to influenza and pneumococcal vaccination not demonstrated. Vaccine,25(23):4631-4640.

Document type: Journal Article
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IRMA ID 10619xPUB29
Title Prevention of community-acquired pneumonia among a cohort of hospitalized elderly: Benefit due to influenza and pneumococcal vaccination not demonstrated
Author Skull, Susan A.
Andrews, Ross M.
Byrnes, Giselle
Kelly, H.
Nolan, T.
Brown, G.
Campbell, D.
Journal Name Vaccine
Publication Date 2007
Volume Number 25
Issue Number 23
ISSN 0264-410X   (check CDU catalogue  open catalogue search in new window)
Start Page 4631
End Page 4640
Total Pages 10
Place of Publication UK
Publisher Elsevier Ltd
Field of Research 0605 - Microbiology
0799 - Other Agricultural and Veterinary Sciences
1107 - Immunology
HERDC Category C1 - Journal Article (DEST)
Abstract Benefits from influenza and 23-valent pneumococcal polysaccharide (23vPPV) vaccines against invasive pneumococcal disease and laboratory confirmed influenza have been well documented. However, their effectiveness against pneumonia remains controversial for community-based elderly ≥65 years. Using a case–cohort design we examined incremental VE of 23vPPV over and above influenza vaccine against hospitalization with community-acquired pneumonia (HCAP) in two large Australian hospitals. 1952 cases (ICD-10-AM codes for pneumonia: J10–J18) and 2927 randomly selected cohort subjects were studied. Vaccination status was confirmed by providers. Benefit against HCAP was not demonstrated in multivariate analysis for influenza vaccine compared with neither vaccine (RR 1.02, 95%CI 0.84–1.20) or for both vaccines compared with influenza vaccine (RR 0.98, 95%CI 0.81–1.18). The current program of funding these vaccines for the elderly is not having a discernable impact on HCAP in this setting.
Keywords Influenza vaccines
Pneumococcal vaccines
Pneumonia
DOI http://dx.doi.org/10.1016/j.vaccine.2007.03.015   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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