Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Differential association of C-reactive protein with adiposity in men and women in an Aboriginal community in northeast Arnhem Land of Australia

Shemesh, Tomer, Rowley, K. G., Jenkins, A, Brimblecombe, Julie K., Best, J. D. and O'Dea, Kerin (2007). Differential association of C-reactive protein with adiposity in men and women in an Aboriginal community in northeast Arnhem Land of Australia. International Journal of Obesity,31(1):103-108.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 15 times in Scopus Article | Citations

Google Scholar Search Google Scholar

IRMA ID 10137xPUB6
Title Differential association of C-reactive protein with adiposity in men and women in an Aboriginal community in northeast Arnhem Land of Australia
Author Shemesh, Tomer
Rowley, K. G.
Jenkins, A
Brimblecombe, Julie K.
Best, J. D.
O'Dea, Kerin
Journal Name International Journal of Obesity
Publication Date 2007
Volume Number 31
Issue Number 1
ISSN 0307-0565   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-33845760593
Start Page 103
End Page 108
Total Pages 6
Place of Publication UK
Publisher Nature Publishing Group
Field of Research 1103 - Clinical Sciences
1111 - Nutrition and Dietetics
HERDC Category C1 - Journal Article (DEST)
Abstract Objective: To examine the relationship between C-reactive protein (CRP), adiposity and other metabolic abnormalities in an Aboriginal community in Northern Australia.

Design: Cross-sectional analysis of data obtained between 2001 and 2003 from 379 Aboriginal people residing in a geographically isolated community.

Results: Mean (95% CI) CRP in women and men was 4.06 cholesterol (3.53, 4.66) mg/l and 3.42 (2.94, 3.97) mg/l, respectively (P=NS). The prevalence of the metabolic syndrome (US National Education program (NCEP) definition) was significantly higher for women than men (41 vs 18%, chi 2=20.94, P<0.001). C-reactive protein correlated strongly with adiposity in women (waist circumference, waist to hip ratio and body mass index; rgreater than or equal to0.514, P<0.01) but much less strongly in men (rless than or equal to0.221, P<0.05). In a multivariate stepwise linear regression model, waist circumference was the strongest independent predictor explaining 35% of CRP concentration variance in women, but only 5.4% in men (WHR). Incremental increases in CRP concentration across four BMI categories were significant in women (P linear trend<0.001) but not in men.

Conclusions: High CRP levels in the surveyed population are consistent with the high prevalence of vascular disease morbidity and mortality in Aboriginal Australians. The relationship of CRP with increasing body fat was strong and consistent in women but not in men. Prospective studies are needed to elucidate the role of CRP (if any) as a predictive marker for cardiovascular events in this high-risk population.
Keywords aboriginal Australians
remoteness
C-reactive protein
metabolic abnormalities
cardiovascular disease
DOI http://dx.doi.org/10.1038/sj.ijo.0803350   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
Versions
Version Filter Type
Access Statistics: 161 Abstract Views  -  Detailed Statistics
Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator