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Enhanced disease surveillance through private health care sector cooperation in Karachi, Pakistan: experience from a vaccine trial

Khan, Mohammad I., Sahito, Shah M., Khan, Mohammad J., Wassan, Shafi M., Shaikh, Abdul W., Maheshwari, Ashok K., Acosta, Camilo J., Galindo, Claudia M., Ochiai, Rion Leon, Rasool, Shahid, Peerwani, Sheeraz, Puri, Mahesh K., Ali, Mohammad, Zafar, Afia, Hassan, Rumina, von Seidlein, Lorenz, Clemens, John D., Nizami, Shaikh Q. and Bhutta, Zulfiqar A. (2006). Enhanced disease surveillance through private health care sector cooperation in Karachi, Pakistan: experience from a vaccine trial. Bulletin of the World Health Organization,84(1):72-77.

Document type: Journal Article
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Title Enhanced disease surveillance through private health care sector cooperation in Karachi, Pakistan: experience from a vaccine trial
Author Khan, Mohammad I.
Sahito, Shah M.
Khan, Mohammad J.
Wassan, Shafi M.
Shaikh, Abdul W.
Maheshwari, Ashok K.
Acosta, Camilo J.
Galindo, Claudia M.
Ochiai, Rion Leon
Rasool, Shahid
Peerwani, Sheeraz
Puri, Mahesh K.
Ali, Mohammad
Zafar, Afia
Hassan, Rumina
von Seidlein, Lorenz
Clemens, John D.
Nizami, Shaikh Q.
Bhutta, Zulfiqar A.
Journal Name Bulletin of the World Health Organization
Publication Date 2006
Volume Number 84
Issue Number 1
ISSN 00429686   (check CDU catalogue  open catalogue search in new window)
Start Page 72
End Page 77
Total Pages 6
Place of Publication Switzerland
Publisher World Health Organization
Abstract Introduction:
In research projects such as vaccine trials, accurate and complete surveillance of all outcomes of interest is critical. In less developed countries where the private sector is the major health-care provider, the private sector must be included in surveillance systems in order to capture all disease of interest. This, however, poses enormous challenges in practice. The process and outcome of recruiting private practice clinics for surveillance in a vaccine trial are described.

Methods:

The project started in January 2002 in two urban squatter settlements of Karachi, Pakistan. At the suggestion of private practitioners, a phlebotomy team was formed to provide support for disease surveillance. Children who had a reported history of fever for more than three days were enrolled for a diagnosis.
Results: Between May 2003 and April 2004, 5540 children younger than 16 years with fever for three days or more were enrolled in the study. Of the children, 1312 (24%) were seen first by private practitioners; the remainder presented directly to study centres. In total, 5329 blood samples were obtained for microbiology. The annual incidence of Salmonella typhi diagnosed by blood culture was 407 (95% confidence interval (95% CI), 368–448) per 100 000/year and for Salmonella paratyphi A was 198 (95% CI, 171–227) per 100 000/year. Without the contribution of private practitioners, the rates would have been 240 per 100 000/year (95% CI, 211–271) for S. typhi and 114 (95% CI, 94–136) per 100 000/year for S. paratyphi A.

Conclusion:

The private sector plays a major health-care role in Pakistan. Our experience from a surveillance and burden estimation study in Pakistan indicates that this objective is possible to achieve but requires considerable effort and confidence building. Nonetheless, it is essential to include private health care providers when attempting to accurately estimate the burden of disease in such settings.
Keywords Epidemiologic surveillance
Vaccination
Clinical trials
Private sector
Salmonella typhi
Pakistan
(source: MeSH, NLM)
Description for Link Link to published version
URL http://www.who.int/bulletin/volumes/84/1/bhutta0106abstract/en/index.html
 
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Created: Wed, 28 Nov 2012, 15:39:52 CST by Teresa Haendel