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Effectiveness of a publicly funded pneumococcal vaccination program against invasive pneumococcal disease among the elderly in Victoria, Australia

Andrews, Ross M., Counahan, Megan L., Hogg, Geoff G. and McIntyre, Peter B. (2004). Effectiveness of a publicly funded pneumococcal vaccination program against invasive pneumococcal disease among the elderly in Victoria, Australia. Vaccine,23(2):132-138.

Document type: Journal Article
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Title Effectiveness of a publicly funded pneumococcal vaccination program against invasive pneumococcal disease among the elderly in Victoria, Australia
Author Andrews, Ross M.
Counahan, Megan L.
Hogg, Geoff G.
McIntyre, Peter B.
Journal Name Vaccine
Publication Date 2004
Volume Number 23
Issue Number 2
ISSN 0264-410X   (check CDU catalogue open catalogue search in new window)
Start Page 132
End Page 138
Total Pages 7
Place of Publication United Kingdom
Publisher Elsevier
Field of Research 0699 - Other Biological Sciences
0799 - Other Agricultural and Veterinary Sciences
1107 - Immunology
HERDC Category C1 - Journal Article (DEST)
Abstract Within Australia, Victoria is the only jurisdiction where the 23-valent polysaccharide pneumococcal vaccine (23vPPV) has been publicly funded for the elderly (aged < or = 65 years). We compared age-specific rates of invasive pneumococcal disease (IPD) for periods before and after implementation of the program, and data from a comparable Australian population that does not have a funded program. Vaccine effectiveness (VE) was estimated using the screening and indirect cohort methods. Compared to the pre-program period, there was a 36% reduction in the reported rates of IPD among persons aged < or = 65 years. Adjusted for under-reporting in the referent rate, the decrease was equivalent to an annual reduction of 112 cases and an estimated 14 deaths among persons < or = 65 years. VE was 71% (95% CI 54-82) using the screening method and 79% (95% CI -14 to 96) by the indirect cohort method. Both point estimates were consistent with the VE expected among persons aged < or = 65 years, although the small number of isolates meant the indirect cohort method was inconclusive at the lower 95% confidence limit. Consideration should be given to publicly funding pneumococcal vaccine for this age group in other settings.
Keywords Australian
Death
diagnosis
Disease
Epidemiology
immunology
Mortality
Pneumococcal Infections
Pneumococcal Vaccines
Pneumonia,Pneumococcal
Population Health
Population Surveillance
prevention & control
Public Health
Vaccination
DOI http://dx.doi.org/10.1016/j.vaccine.2004.06.016   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Mon, 26 Nov 2007, 15:07:47 CST