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Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses

Bihl, Florian, Frahm, Nicole, Digiammarino, Loriana Di, Sidney, John, John, Mina, Yusim, Karina, Woodberry, Tonia, Sango, Kaori, Hewitt, Hannah S., Henry, Leah, Linde, Caitlyn H., Chisholm, John V. III, Zaman, Tauheed M., Pae, Eunice, Mallal, Simon, Walker, Bruce D., Sette, Alessandro, Korber, Bette T., Heckerman, David and Brander, Christian (2006). Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses. Journal of Immunology,176(7):4094-4101.

Document type: Journal Article
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Title Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses
Author Bihl, Florian
Frahm, Nicole
Digiammarino, Loriana Di
Sidney, John
John, Mina
Yusim, Karina
Woodberry, Tonia
Sango, Kaori
Hewitt, Hannah S.
Henry, Leah
Linde, Caitlyn H.
Chisholm, John V. III
Zaman, Tauheed M.
Pae, Eunice
Mallal, Simon
Walker, Bruce D.
Sette, Alessandro
Korber, Bette T.
Heckerman, David
Brander, Christian
Journal Name Journal of Immunology
Publication Date 2006
Volume Number 176
Issue Number 7
ISSN 0022-1767   (check CDU catalogue  open catalogue search in new window)
Start Page 4094
End Page 4101
Total Pages 8
Place of Publication US
Publisher The American Association of Immunologists
Field of Research 1107 - Immunology
HERDC Category C1 - Journal Article (DEST)
Abstract Immunodominance is variably used to describe either the most frequently detectable response among tested individuals or the strongest response within a single individual, yet factors determining either inter- or intraindividual immunodominance are still poorly understood. More than 90 individuals were tested against 184 HIV- and 92 EBV-derived, previously defined CTL epitopes. The data show that HLA-B-restricted epitopes were significantly more frequently recognized than HLA-A- or HLA-C-restricted epitopes. HLA-B-restricted epitopes also induced responses of higher magnitude than did either HLA-A- or HLA-C-restricted epitopes, although this comparison only reached statistical significance for EBV epitopes. For both viruses, the magnitude and frequency of recognition were correlated with each other, but not with the epitope binding affinity to the restricting HLA allele. The presence or absence of HIV coinfection did not impact EBV epitope immunodominance patterns significantly. Peptide titration studies showed that the magnitude of responses was associated with high functional avidity, requiring low concentration of cognate peptide to respond in in vitro assays. The data support the important role of HLA-B alleles in antiviral immunity and afford a better understanding of the factors contributing to inter- and intraindividual immunodominance
Keywords Acquired Immunodeficiency Syndrome
Alleles
Amino Acid Sequence
chemistry
Epitopes,T-Lymphocyte
Epstein-Barr Virus Infections
genetics
Herpesvirus 4,Human
Hiv-1
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
Immunodominant Epitopes
immunology
In Vitro
metabolism
Molecular Sequence Data
T-Lymphocytes,Cytotoxic
virology
Description for Link Link to abstract
URL http://www.ncbi.nlm.nih.gov/pubmed/16547245
 
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Created: Mon, 26 Nov 2007, 15:07:47 CST