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Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux

Chang, Anne B., Lasserson, T., Kiljander, T., Connor, Frances L., Gaffney, J. and Garske, L. (2006). Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ: British Medical Journal,332(7532):11-14.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 7
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IRMA ID 10491xPUB127
Title Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux
Author Chang, Anne B.
Lasserson, T.
Kiljander, T.
Connor, Frances L.
Gaffney, J.
Garske, L.
Journal Name BMJ: British Medical Journal
Publication Date 2006
Volume Number 332
Issue Number 7532
ISSN 0959-8154   (check CDU catalogue open catalogue search in new window)
Start Page 11
End Page 14
Total Pages 4
Place of Publication UK
Publisher BMJ Group
Field of Research 1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract OBJECTIVE: To evaluate the efficacy of treatment for gastro-oesophageal reflux disease (GORD) on chronic cough in children and adults without an underlying respiratory disease. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Cochrane, Medline, and Embase databases, references from review articles. INCLUDED STUDIES: Randomised controlled trials on GORD treatment for cough in children and adults without primary lung disease. Two reviewers independently selected studies and extracted paediatric and adult data on primary (clinical failure) and secondary outcomes. RESULTS: 11 studies were included. Meta-analysis was limited to five studies in adults that compared proton pump inhibitors with placebo. All outcomes favoured proton pump inhibitors: the odds ratio for clinical failure (primary outcome) was 0.24 (95% confidence interval 0.04 to 1.27); number needed to treat (NNT) was 5 (harm 50 to infinity to benefit 2.5). For secondary outcomes, the standardised mean difference between proton pump inhibitors and placebo was -0.51 (-1.02 to 0.01) for mean cough score at the end of the trial and -0.29 (-0.62 to 0.04) for change in cough score at the end of the trial. Subgroup analysis with generic inverse variance analysis showed a significant mean change in cough (-0.41 SD units, -0.75 to -0.07). CONCLUSION: Use of a proton pump inhibitor to treat cough associated with GORD has some effect in some adults. The effect, however, is less universal than suggested in consensus guidelines on chronic cough and its magnitude of effect is uncertain.
Keywords Australia
Children
Chronic Disease
Cough
Disease
drug therapy
etiology
Gastroesophageal Reflux
interventions
Lung
Meta-Analysis
Odds Ratio
outcomes
Proton Pumps
Randomized Controlled Trials
systematic review
DOI http://dx.doi.org/10.1136/bmj.38677.559005.55   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Mon, 26 Nov 2007, 15:07:47 CST