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Plasmodium knowlesi malaria in children

Barber, Bridget E., William, Timothy, Jikal, Mohammad, Jilip, Jenarun, Dhararaj, Prabakaran, Menon, Jayaram, Yeo, Tsin W. and Anstey, Nicholas M. (2011). Plasmodium knowlesi malaria in children. Emerging Infectious Diseases,17(5):814-820.

Document type: Journal Article
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IRMA ID 82057923xPUB193
Title Plasmodium knowlesi malaria in children
Author Barber, Bridget E.
William, Timothy
Jikal, Mohammad
Jilip, Jenarun
Dhararaj, Prabakaran
Menon, Jayaram
Yeo, Tsin W.
Anstey, Nicholas M.
Journal Name Emerging Infectious Diseases
Publication Date 2011
Volume Number 17
Issue Number 5
ISSN 1080-6059   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-79955763386
Start Page 814
End Page 820
Total Pages 7
Place of Publication United States
Publisher U.S. Department of Health and Human Services, Centers for Disease Control and Prevention
HERDC Category C1 - Journal Article (DEST)
Abstract Plasmodium knowlesi can cause severe malaria in adults; however, descriptions of clinical disease in children are lacking. We reviewed case records of children (age <15 years) with a malaria diagnosis at Kudat District Hospital, serving a largely deforested area of Sabah, Malaysia, during January–November 2009. Sixteen children with PCR-confirmed P. knowlesi monoinfection were compared with 14 children with P. falciparum monoinfection diagnosed by microscopy or PCR. Four children with knowlesi malaria had a hemoglobin level at admission of <10.0 g/dL (minimum lowest level 6.4 g/dL). Minimum level platelet counts were lower in knowlesi than in falciparum malaria (median 76,500/µL vs. 156,000/μL; p = 0.01). Most (81%) children with P. knowlesi malaria received chloroquine and primaquine; median parasite clearance time was 2 days (range 1–5 days). P. knowlesi is the most common cause of childhood malaria in Kudat. Although infection is generally uncomplicated, anemia is common and thrombocytopenia universal. Transmission dynamics in this region require additional investigation.
Keywords Plasmodium knowlesi
malaria parasite
P. knowlesi infections
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