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Molecular investigations of a locally acquired case of Melioidosis in Southern AZ, USA

Engelthaler, David M., Bowers, Jolene, Schupp, James A., Pearson, Talima, Ginther, Jennifer, Hornstr, Heidie M., Dale, Julia, Stewart, Tasha, Sunenshine, Rebecca, Waddell, Victor, Levy, Craig, Gillece, John, Price, Lance B., Contente, Tania, Beckstrom-Sternberg, Stephen M., Blaney, David D., Wagner, David M., Mayo, Mark J., Currie, Bart J., Keim, Paul and et al. (2011). Molecular investigations of a locally acquired case of Melioidosis in Southern AZ, USA. PLoS Neglected Tropical Diseases,5(10):e1347.

Document type: Journal Article
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IRMA ID kmckayxPUB22
Title Molecular investigations of a locally acquired case of Melioidosis in Southern AZ, USA
Author Engelthaler, David M.
Bowers, Jolene
Schupp, James A.
Pearson, Talima
Ginther, Jennifer
Hornstr, Heidie M.
Dale, Julia
Stewart, Tasha
Sunenshine, Rebecca
Waddell, Victor
Levy, Craig
Gillece, John
Price, Lance B.
Contente, Tania
Beckstrom-Sternberg, Stephen M.
Blaney, David D.
Wagner, David M.
Mayo, Mark J.
Currie, Bart J.
Keim, Paul
et al.
Journal Name PLoS Neglected Tropical Diseases
Publication Date 2011
Volume Number 5
Issue Number 10
ISSN 1935-2735   (check CDU catalogue open catalogue search in new window)
Start Page e1347
Total Pages 6
Place of Publication United States
Publisher Public Library of Science
HERDC Category C1 - Journal Article (DEST)
Abstract Melioidosis is caused by Burkholderia pseudomallei, a Gram-negative bacillus, primarily found in soils in Southeast Asia and northern Australia. A recent case of melioidosis in non-endemic Arizona was determined to be the result of locally acquired infection, as the patient had no travel history to endemic regions and no previous history of disease. Diagnosis of the case was confirmed through multiple microbiologic and molecular techniques. To enhance the epidemiological analysis, we conducted several molecular genotyping procedures, including multi-locus sequence typing, SNP-profiling, and whole genome sequence typing. Each technique has different molecular epidemiologic advantages, all of which provided evidence that the infecting strain was most similar to those found in Southeast Asia, possibly originating in, or around, Malaysia. Advancements in new typing technologies provide genotyping resolution not previously available to public health investigators, allowing for more accurate source identification.

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