Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia

William, Timothy, Menon, Jayaram, Rajahram, Giri, Chan, Leslie, Ma, Gordon, Donaldson, Samantha, Khoo, Serena, Fredrick, Charlie, Jelip, Jenarun, Anstey, Nicholas M. and Yeo, Tsin W. (2011). Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia. Emerging Infectious Diseases,17(7):1248-1255.

Document type: Journal Article
Attached Files (Some files may be inaccessible until you login with your CDU eSpace credentials)
Name Description MIMEType Size Downloads
Download this reading Anstey_30189.pdf Published version application/pdf 288.33KB 242
Reading the attached file works best in Firefox, Chrome and IE 9 or later.

IRMA ID kmckayxPUB4
Title Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia
Author William, Timothy
Menon, Jayaram
Rajahram, Giri
Chan, Leslie
Ma, Gordon
Donaldson, Samantha
Khoo, Serena
Fredrick, Charlie
Jelip, Jenarun
Anstey, Nicholas M.
Yeo, Tsin W.
Journal Name Emerging Infectious Diseases
Publication Date 2011
Volume Number 17
Issue Number 7
ISSN 1080-6040   (check CDU catalogue open catalogue search in new window)
Start Page 1248
End Page 1255
Total Pages 8
Place of Publication United States
Publisher U.S. Department of Health and Human Services, Centers for Disease Control and Prevention
HERDC Category C1 - Journal Article (DEST)
Abstract The simian parasite Plasmodium knowlesi causes severe human malaria; the optimal treatment remains unknown. We describe the clinical features, disease spectrum, and response to antimalarial chemotherapy, including artemether-lumefantrine and artesunate, in patients with P. knowlesi malaria diagnosed by PCR during December 2007–November 2009 at a tertiary care hospital in Sabah, Malaysia. Fifty-six patients had PCR-confirmed P. knowlesi monoinfection and clinical records available for review. Twenty-two (39%) had severe malaria; of these, 6 (27%) died. Thirteen (59%) had respiratory distress; 12 (55%), acute renal failure; and 12, shock. None experienced coma. Patients with uncomplicated disease received chloroquine, quinine, or artemether-lumefantrine, and those with severe disease received intravenous quinine or artesunate. Parasite clearance times were 1–2 days shorter with either artemether-lumefantrine or artesunate treatment. P. knowlesi is a major cause of severe and fatal malaria in Sabah. Artemisinin derivatives rapidly clear parasitemia and are efficacious in treating uncomplicated and severe knowlesi malaria.
DOI http://dx.doi.org/10.3201/eid1707.101017   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


© copyright

Every reasonable effort has been made to ensure that permission has been obtained for items included in CDU eSpace. If you believe that your rights have been infringed by this repository, please contact digitisation@cdu.edu.au.

 
Versions
Version Filter Type
Access Statistics: 134 Abstract Views, 242 File Downloads  -  Detailed Statistics
Created: Wed, 03 Jul 2013, 13:52:04 CST by Iwona Rohoza