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IL-8 responsiveness defines a subset of CD8 T cells poised to kill

Hess, Christoph, Means, Terry K., Autissier, Patrik, Woodberry, Tonia, Altfeld, Marcus, Addo, Marylyn M., Frahm, Nicole, Brander, Christian, Walker, Bruce D. and Luster, Andrew D. (2004). IL-8 responsiveness defines a subset of CD8 T cells poised to kill. Blood,104(12):3463-3471.

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Title IL-8 responsiveness defines a subset of CD8 T cells poised to kill
Author Hess, Christoph
Means, Terry K.
Autissier, Patrik
Woodberry, Tonia
Altfeld, Marcus
Addo, Marylyn M.
Frahm, Nicole
Brander, Christian
Walker, Bruce D.
Luster, Andrew D.
Journal Name Blood
Publication Date 2004
Volume Number 104
Issue Number 12
ISSN 0006-4971   (check CDU catalogue open catalogue search in new window)
Start Page 3463
End Page 3471
Total Pages 9
Place of Publication Washington, DC
Publisher The Americain Society of Hematology
Field of Research 1103 - Clinical Sciences
1102 - Cardiovascular Medicine and Haematology
1114 - Paediatrics and Reproductive Medicine
HERDC Category C1 - Journal Article (DEST)
Abstract CD8 T cells play a key role in host defense against intracellular pathogens. Efficient migration of these cells into sites of infection is therefore intimately linked to their effector function. The molecular mechanisms that control CD8 T-cell trafficking into sites of infection and inflammation are not well understood, but the chemokine/chemokine receptor system is thought to orchestrate this process. Here we systematically examined the chemokine receptor profile expressed on human CD8 T cells. Surprisingly, we found that CXC chemokine receptor 1 (CXCR1), the predominant neutrophil chemokine receptor, defined a novel interleukin-8/CXC ligand 8 (IL-8/CXCL8)-responsive CD8 T-cell subset that was enriched in perforin, granzyme B, and interferon-gamma (IFNgamma), and had high cytotoxic potential. CXCR1 expression was down-regulated by antigen stimulation both in vitro and in vivo, suggesting antigen-dependent shaping of the migratory characteristics of CD8 T cells. On virus-specific CD8 T cells from persons with a history of Epstein-Barr virus (EBV) and influenza infection, CXCR1 expression was restricted to terminally differentiated effector memory cells. In HIV-1 infection, CXCR1-expressing HIV-1-specific CD8 T cells were present only in persons who were able to control HIV-1 replication during structured treatment interruptions. Thus, CXCR1 identifies a subset of CD8 T cells poised for immediate cytotoxicity and early recruitment into sites of innate immune system activation
Keywords Antigens
CD8-Positive T-Lymphocytes
Immunologic Memory
In Vitro
T-Lymphocyte Subsets
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