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Mechanisms for a novel immune evasion strategy in the scabies mite Sarcoptes scabiei: A multigene family of inactivated serine proteases

Holt, Deborah C., Fischer, Katja, Allen, George E., Wilson, Danny, Wilson, Peter, Slade, Robert, Currie, Bart J., Walton, Shelley F. and Kemp, David J. (2003). Mechanisms for a novel immune evasion strategy in the scabies mite Sarcoptes scabiei: A multigene family of inactivated serine proteases. Journal of Investigative Dermatology,121(6):1419-1424.

Document type: Journal Article
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Title Mechanisms for a novel immune evasion strategy in the scabies mite Sarcoptes scabiei: A multigene family of inactivated serine proteases
Author Holt, Deborah C.
Fischer, Katja
Allen, George E.
Wilson, Danny
Wilson, Peter
Slade, Robert
Currie, Bart J.
Walton, Shelley F.
Kemp, David J.
Journal Name Journal of Investigative Dermatology
Publication Date 2003
Volume Number 121
Issue Number 6
ISSN 0022-202X   (check CDU catalogue  open catalogue search in new window)
Start Page 1419
End Page 1424
Total Pages 6
Place of Publication Danvers, MA, US
Publisher Nature Publishing Group
Field of Research 1103 - Clinical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract Parasitic infestation of the skin by the mite Sarcoptes scabiei is a significant problem worldwide, particularly in socially disadvantaged communities. A multigene family of at least 24 homologs of a serine protease allergen have been identified in S. scabiei. Surprisingly, the products of all but one of these genes are predicted to be catalytically inactive, due to mutations at a critical triad of amino acids at the active site. We discuss the possibility that these genes for inactivated proteases have been conserved because they mediate a novel host defense evasion strategy that the mite has evolved as an adaptation to parasitism of the epidermis. The identification of this family, and elucidation of its value to the parasite, may present an unanticipated approach to protective vaccination.
Keywords families
Multigene Family
Sarcoptes scabiei
Scabies
 
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Created: Mon, 26 Nov 2007, 15:07:47 CST